Stress(Rost,etc)CytogeneticinsultTNF FasDisturbing the Ca2+ homeo sta sisDNA damage11death receptorP53CBaxAdaptur(FADD,TRADD)mitochondrial cyt cleakageBidCaspase8BadApaf-l-cytc-dATPbcl-X-Apaf-lCaspase9Caspase3cell apoptosis
Apoptotic PathwaysFas ligandDeathreceptorsSurvivalfactorsIndependent stimuliFasdeath-inducingDISC14-3-signaling complexFADDBaxFas-associatingproteinwithBidCalcineurineKinasesdeathdomainPP1a(Akt,MAPKCaspase8PKA,Rsks,tBidPAK)Bcl-XLBadCaspase9CytApaf-1dATPDownstreamcaspasesfrends in Cell Biology
death-inducing signaling complex Fas-associating protein with death domain Apoptotic Pathways
MitochondrialMembrane Permeabilization(MMP) in Apoptotic ProcessJNK/SAPKBimBax/BakNOp53MMPHVB-Xt-BidTR3BadcaspasesFatty acidsinducersVprROSCa24CeramideLipid poreBax/BakCardiolipinBe1-2MMP口ANTBcl-XL福日YDAChsp70Felease ofimtermembraneprotenDepletionorGSH/NAD(P)HROS generationCon-CessatlonofATPssnthesisPro-caspasesseguencesAIFCytochromeAntioxidantofMMPdifferenthsp10/60cnzymesSmac/DinblohydrolasesCaspase-CaspaseRedoxand bioenergeticindependentactivaliondeath effectorscatastroplhy
Mitochondrial Membrane Permeabilization (MMP) in Apoptotic Process
ER and ApoptosisfMatrixLPUP12Caspases-3 and-7?美BCLXApoptosomeOPJNKTRAF2oligomerizes9andactivatescaspase-12PCalpainactivatesProcaspase-12MKK4c-ROScaspase-12MKK7otm-CalpainCa2+ASK-1ECa2+IRE1eaCa2+IRE1ERstressTRENiisMPhamaaogicalSeenzs
ER and Apoptosis
Cross-talking among Organelles and Molecules in ApoptosisCHOPNucleusERBcl-2Peg3/Pw1Lp53UPRdownrequlationoWstressa-inducedMMPC0Bcl-XL?APUMAHsp70Lysosomesxap53BaxBcl-2-t-Bcl-XLTRECa+24BidCathepsin-latior300OCm-calpain005Q?at-BidMMPMMP12CaspaseProlineoxidaseROSTp53AIP1AmCaspaseGD3-inducedMMPcascadeGD3Caspase-2Procaspase-9MitochondrionMMFDiablo/Smac14福Bcl-2CaspasecascadeCaspaseCyt.clkBa/NFkBATFcascadDApaf-GolgiIAPProcapase-XIAPProcaspase-9hCaspase-9Caspase-3activationactivation
Cross-talking among Organelles and Molecules in Apoptosis