STRESS AND STRESS.RELATEDDISEASESPathophysiology Department, ShiHeZi Medical College,HUST
STRESS AND STRESSRELATED DISEASES Pathophysiology Department, ShiHeZi Medical College, HUST
Contents1. Concepts: general adaptation syndromestress,stressor2.Mechanism-stress responseNeuroendocrine: LC-NE/sympathetic,HPAHumoral and cellular:APP,HSP3.Functional metabolic alteration4. Stress-related diseases: stress ulcer5.Prevention and treatment principle6. Case discussion
1. Concepts: general adaptation syndrome, stress, stressor 2. Mechanism-stress response • Neuroendocrine: LC-NE/sympathetic, HPA • Humoral and cellular: APP, HSP 3. Functional metabolic alteration 4. Stress-related diseases: stress ulcer 5. Prevention and treatment principle 6. Case discussion Contents
(From a wood engraving"The Light"by Fritz Eichenberg)RELIEFFROMSTRESSThe Physiology and Pathology Of Exposure ToHans SelyeSTRESS(1907-1982)HansSelye,MDDSeFRs.(190)
Hans Selye (1907-1982)
General Adaptation Syndrome(GAS)Specific symptomsDifferent diseasesNon-specific symptomsA serial of non-specific signs and symptoms causedby various strong stimulus
• General Adaptation Syndrome (GAS) A serial of non-specific signs and symptoms caused by various strong stimulus. Different diseases Specific symptoms Non-specific symptoms
General Principle of StressStimulusDisturbance of homeostasisAdaptativeresponse→HomeostasisDiseases or symptomsA generaladaptative response in order to copewith the altered homeostasis
A general adaptative response in order to cope with the altered homeostasis. Stimulus Diseases or symptoms Disturbance of homeostasis Adaptative response General Principle of Stress Homeostasis