HypoxiaPathophysiology departmentShiHeZi Medical College
Hypoxia Pathophysiology department ShiHeZi Medical College
ConceptTissue cells can'tobtain enough oxygenorcan'tfully utilize oxygenmetabolic, functional and structural changesOxgen supply=CaO,xQOxygenconsumption=（CaO,-CvO,)×Q
Concept Oxgen supply = CaO2× Q Oxygen consumption =（CaO2－CvO2）× Q Tissue cells can’t obtain enough oxygen or can’t fully utilize oxygen metabolic, functional and structural changes
Parameters ofbloodgasPartial pressureofO,(PO,)PaO,100mmHg,PvO240mmHgO,content（CO,)=CO,maxX SO,+dissolved O,Ca0,19ml/dl，Cv0,14ml/dlO,capacity（CO,max）=1.34m/g×Hbg/dlCO,- dissolved 02× 100%O2saturation（SO,）=CO,maxSv0270%Sa0,95%
CO2－dissolved O2 CO2max O2 saturation（SO2）= ×100% SaO2 95%, SvO2 70% Parameters of blood gas Partial pressure of O2（PO2） PaO2 100mmHg , PvO2 40 mmHg O2 content（CO2）= CO2max×SO2 + dissolved O2 CaO2 19ml/dl , CvO2 14ml/dl O2 capacity（CO2max）= 1.34 ml/g × Hb g/dl
100908o7060Suogeies502403020101o102030405060708090100P.Oz (mmHg)Dissociation curve of oxyhemoglobin
Dissociation curve of oxyhemoglobin
Total2210018O,combined80withHbo14Uogeinesq%601040Pso20DissolvedO80600601002040oPO(mmHg)