Once Tyr-Phosphorylated, the IRK activitytrigerrs a number of signaling pathwaysPhosphatidylinositol3.MembranePhosphatehydroxykinase,makesgroups00000000PIP2,PIP3PRSSSignalSignalGrb2,Sos,activatesRasPLLYIRSPhosphateActivationofPLCGrb2GDPPI(3)KPI(4)P,PI(4,5)P2SosRasPI(3.4)P2. PI(3,4,5)PaGTPRas+￥SignalSignalSignalevnyetstonJonnwiyandSens,ind.Nttig
Once Tyr-Phosphorylated, the IRK activity trigerrs a number of signaling pathways ◼ Phosphatidylinositol 3- hydroxy kinase, makes PIP2,PIP3 ◼ Grb2, Sos, activates Ras ◼ Activation of PLC
Receptor TyrosineKinasesOUTSIDEEGFEGFEGFOFCELLbindingsitenaiolamembraneActivedimer天KCYTOSOLTyrosinekinase凯TransautophotphoryiationTyTyrCytosolic具TTvrtallSignalrarsmussioSH2-somair(a)Structureoftheepidermal(b)ActivationoftheEGFreceptorgrowthfactor(EGF)receptor@Addison Wesley Longman, Inc
Receptor Tyrosine Kinases