Regulation of Renal Potassium Excretion*Filtration,reabsorptionandsecretionofpotassiumSecretionof potassiuminthedistalandcollectingtubulesReabsorptionofKinthedistalandcollectingtubules,intercalatedcells,with H+/K+-ATPase (proton pump) forreabsorptionofKt
Regulation of Renal Potassium Excretion Filtration, reabsorption and secretion of potassium Secretion of potassium in the distal and collecting tubules Reabsorption of K in the distal and collecting tubules, intercalated cells, with H+ /K+ -ATPase (proton pump) for reabsorption of K+
Regulation of Renal Potassium ExcretionFiltration,reabsorption and secretion ofpotassiumSecretion of potassium in the distal and collectingtubulesReabsorption ofK in the distal and collecting tubulesintercalated cells, with H+/K+-ATPase(protonpump)forreabsorptionofKtFactors influencing excretion of K+ by the distal andcollecting tubules
Regulation of Renal Potassium Excretion Filtration, reabsorption and secretion of potassium Secretion of potassium in the distal and collecting tubules Reabsorption of K in the distal and collecting tubules intercalated cells, with H+ /K+ -ATPase (proton pump) for reabsorption of K+ Factors influencing excretion of K+ by the distal and collecting tubules
Factors Influencing Excretion of K+ bythe Distal and Collecting TubulesAldosteroneactivates Na+/K+ATPase,increase membrane permeability to K*[K+] intheECF Flow rate of tubular fluid in the distal tubule* pH of ECFJpH inhibits Na*/K+ATPase
Factors Influencing Excretion of K+ by the Distal and Collecting Tubules Aldosterone — activates Na+/K+ATPase, increase membrane permeability to K [K+] in the ECF Flow rate of tubular fluid in the distal tubule pH of ECF —↓pH inhibits Na+/K+ATPase
Factors InfluencingExcretion of K+ by theDistal and Collecting Tubulesbloodlumen+NatAldNatCI+CI④[K*]↑KtKtAdrenalgianflowrate+?Principal Cell3CO2CO2[H+ ]↑HCO1④CICIK+Intercalated Cell
+ lumen blood Principal Cell K+ Na+ Na+ K+ ClClK+ [K+ ]↑ ② ③ CO2 HCO3 - ClClH + K+ CO2 Intercalated Cell [H+ ]↑ flow rate ① Factors Influencing Excretion of K+ by the Distal and Collecting Tubules + + Ald + + + - +
Maintenance of Potassium HomeostasisDistributionofpotassiumacrossthecellmembraneRegulationofrenalpotassiumexcretionExcretionofKbytheColonalsocontrolledbyaldosterone
Maintenance of Potassium Homeostasis Distribution of potassium across the cell membrane Regulation of renal potassium excretion Excretion of K by the Colon also controlled by aldosterone