The discovery of p53 DISCOVERY OF OF p53(I) SIMIAN VIRUS 40 @ Hamster Transformed cells Flbroblasts Ag 53 kDa Lane et al.,1979 mAb PAb419 Kress et al.,1979 Linzer et al.,1979 Co-precipitation of SV40 large T Antigen Deleo et al.,1979 and a cellular protein of 53 kDa
The discovery of p53
The role of p53 p53:A TUMOR SUPPRESSOR GENE p53:A TUMOR SUPPRESSOR GENE ?(Ill) MP53+ activated Ha-ras HUMAN TUMORS Rat embryonic fibroblasts mutant p53+ activated Ha-ras Rat embryonic CHROMOSOME 17 fibroblasts 2004 24 27 Mutant+wt p53+ 120 activated Ha-ras Rat embryonic fibroblasts Fink Nigro et al.1989 Takahashi et al.1989 MISSENSE MUTATIONS
The role of p53