肿瘤抑制基因 肿瘤抑制基因(tumor suppressor gene) 抑癌基因、抗癌基因(anti-oncogene) 隐性癌基因(recessive oncogene) 正常细胞中抑制肿瘤发生的基因 细胞杂交证明逆转肿瘤细胞表型 Tumor cell from Plate 2 Wild-type cell First discovered in 1960s by Henry Harris. Wild-type cell
肿瘤抑制基因 肿瘤抑制基因（tumor suppressor gene） 抑癌基因、抗癌基因（anti-oncogene） 隐性癌基因（recessive oncogene） ——正常细胞中抑制肿瘤发生的基因 细胞杂交证明逆转肿瘤细胞表型
86年首次发现肿瘤抑制基因RB,共十几种 -1 -13 13 -13 13 -1、-13 抑制细胞 -13 1、13 恶性表达 13
-13 13 -13 13 抑制细胞 恶性表达 -1、 -13 1、 13 -1、-13 1、 13 86年首次发现肿瘤抑制基因RB，共十几种
The roles of anti-oncogene Normal cell cycle Beginning Cell of cycle divides (mitosis】 M Cell enlarges and makes Cell prepares new proteins to divide Cell rests、 Cell Restriction point:cell replicates decides whether its DNA to commit itself to the complete cycle
Scientific American, 1996 The roles of anti-oncogene Normal cell cycle
The roles of anti-oncogene Cell Cycle is controlled by genes. Interphase 9 Hours 10 Gi: Hours Cell grows and DNA replication carries out norma and chromosome metabolism: duplication organelles duplicate G Cell grows and prepares for mitosis 的游 Metaphase 4 Hours 1 Hour Mtosis (M Pnase)
The roles of anti-oncogene
The roles of anti-oncogene Genes control Cell division by cytokines. GROWTH INHIBITORS GROWTH FACTORS (TGF-B,p53,others) (EGF,PDGF) Stimulate CDK Inhibitors eg,*p16NK4a】 Actlvate Inactivate *Cvclins D,eDK4,6女 Cyelin E/CDK2
Genes control Cell division by cytokines. The roles of anti-oncogene