Drugs Affecting Blood
Drugs Affecting Blood
three important dysfunctions of blood thrombosis,bleeding,and anemia. Thrombosis-the formation of an unwanted clot within the blood vessels or heart. ■ Bleeding disorders involving failure of hemostasis are less common than thromboembolic diseases and include hemophilia and vitamin K deficiency. Anemias caused by nutritional deficiencies can be treated with either dietary or pharmaceutical supplementation
three important dysfunctions of blood ◼ thrombosis, bleeding, and anemia. Thrombosis-the formation of an unwanted clot within the blood vessels or heart. ◼ Bleeding disorders involving failure of hemostasis are less common than thromboembolic diseases and include hemophilia and vitamin K deficiency. ◼ Anemias caused by nutritional deficiencies can be treated with either dietary or pharmaceutical supplementation
NORMAL RESPONSE TO VASCULAR TRAUMA Physical trauma to the vascular system, such as a puncture or cut,initiates a complex series of interactions between platelets,endothelial cells,and the coagulation cascade.This results in the formation of a platelet-fibrin plug
NORMAL RESPONSE TO VASCULAR TRAUMA ◼ Physical trauma to the vascular system, such as a puncture or cut, initiates a complex series of interactions between platelets, endothelial cells, and the coagulation cascade. This results in the formation of a platelet-fibrin plug
A.Formation of a clot Clot formation requires platelet activation and aggregation,followed by formation of thrombin
A. Formation of a clot ◼ Clot formation requires platelet activation and aggregation, followed by formation of thrombin
Role of platelets Platelets respond to vascular trauma by "activation"processes,which involve three steps:adhesion to the site of injury,release of intracellular granules, and aggregation of the platelets
Role of platelets ◼ Platelets respond to vascular trauma by "activation" processes, which involve three steps: adhesion to the site of injury, release of intracellular granules, and aggregation of the platelets