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Role of fibrin Local stimulation of the coagulation cascade by factors released from the injured tissue and platelets results in the formation of thrombin (Factor II). In turn,thrombin,a serine protease, catalyzes the conversion of fibrinogen to fibrin,which is incorporated into the plug
Role of fibrin ◼ Local stimulation of the coagulation cascade by factors released from the injured tissue and platelets results in the formation of thrombin (Factor II). In turn, thrombin, a serine protease, catalyzes the conversion of fibrinogen to fibrin, which is incorporated into the plug
Thrombus versus embolus A clot that adheres to a vessel wall is called a thrombus,whereas an intravascular clot that floats within the blood is termed an embolus.Thus,a detached thrombus becomes an embolus
Thrombus versus embolus ◼ A clot that adheres to a vessel wall is called a thrombus, whereas an intravascular clot that floats within the blood is termed an embolus. Thus, a detached thrombus becomes an embolus