Antidepressant drugs
Antidepressant drugs
Overview Affecting energy,sleep,appetite,libido and the ability to function. Different from schizophrenia Due to a deficiency of monoamines such as norepinephrine and serotonin at certain key sites in the brain
Overview ◼ Affecting energy, sleep, appetite, libido and the ability to function. ◼ Different from schizophrenia ◼ Due to a deficiency of monoamines such as norepinephrine and serotonin at certain key sites in the brain
Tricyclic/polycyclic antidepressants Block norepinephrine,and serotonin uptake into the neuron. Imipramine,amitriptyline,desipramine All have similar therapeutic efficacy,and the choice of drug depends on tolerance of side effects and duration of action
Tricyclic /polycyclic antidepressants ◼ Block norepinephrine, and serotonin uptake into the neuron. ◼ Imipramine, amitriptyline, desipramine ◼ All have similar therapeutic efficacy, and the choice of drug depends on tolerance of side effects and duration of action
Mode of action Inhibition of neurotransmitter uptake: TCA inhibit the neuronal reuptake of norepinephrine,and serotonin into presynaptic nerve terminals. Blocking of receptors:The TCAs also block serotonergic,alpha-adrenergic, histamine,and muscarinic receptors
Mode of action ◼ Inhibition of neurotransmitter uptake: TCA inhibit the neuronal reuptake of norepinephrine, and serotonin into presynaptic nerve terminals. ◼ Blocking of receptors: The TCAs also block serotonergic, alpha-adrenergic, histamine, and muscarinic receptors
actions TCAs elevate mood,improve mental alertness,increase physical activity,and reduce morbid preoccupation in 50 to 70%of individuals with major depression
actions ◼ TCAs elevate mood, improve mental alertness, increase physical activity, and reduce morbid preoccupation in 50 to 70% of individuals with major depression