Anxiolytic and hypnotic drugs
Anxiolytic and hypnotic drugs
overview Anxiety is an unpleasant state Disorders involving anxiety are the most common mental disturbances Function clinically as both anxiolytic and hypnotic (sleep-inducing)agents
overview ◼ Anxiety is an unpleasant state ◼ Disorders involving anxiety are the most common mental disturbances ◼ Function clinically as both anxiolytic and hypnotic (sleep-inducing) agents
benzodiazepines The most widely used anxiolytic drugs More effective and safer than barbiturates and meprobamate
benzodiazepines ◼ The most widely used anxiolytic drugs ◼ More effective and safer than barbiturates and meprobamate
Mode of action Binding of y-aminobutyric acid to its receptor -Triggers an opening of a chloride channel ■( Causes a small hyperpolarization that moves the postsynaptic potential away
Mode of action ◼ Binding of -aminobutyric acid to its receptor ◼ Triggers an opening of a chloride channel ◼ Causes a small hyperpolarization that moves the postsynaptic potential away
eptor empty agonists) Chloride channel Empty receptor is inactive,and the coupled GABA 0阳cepto chloride channel Is closed Benzodiazepine receptor eptor GABA ilng GABA GABA Binding of GABA causes GABA receptor the chloride lon channel to open. eptor Benzodiazepin ing GABA benzodiazepine GABA Binding of GABA is GABA recepto enhanced by benzo- Cr hyperpolarizes cell making lifficult to depolarize and therefore on. neural excitability