。 Antimicrobial Agents: General Consideration The drugs that inhibit Antibacterial drugs or kill the bacterial Antibiotics The agents which are produced by microbes,could inhibit or kill other microbes
Antimicrobial Agents: General Consideration Antibiotics Antibacterial drugs The drugs that inhibit or kill the bacterial The agents which are produced by microbes, could inhibit or kill other microbes
Chemotherapeutic index A、ED90/LD10 B、ED50/LD50 C、LD90/ED50 D、LD50/ED50 E、LD95/ED5
Chemotherapeutic index A、ED90/LD10 B、ED50/LD50 C、LD90/ED50 D、LD50/ED50 E、LD95/ED5
Mechanism of action Polymyxin B-lactam Polyenes Vancomycin Azoles Cell wall Quinolones DNA← THF A 505 50S 60 DHFA Rifampin Plasma membrane Tetracyclines TMP Aminoglycosides Sulfonamides PABA Macrolides Chloramphenicol Lincomycin
Mechanism of action Quinolones -lactam Vancomycin DNA Plasma membrane PABA DHF A THF A 50S 50S 50S 30S 30S 30S mRNA Rifampin TMP Sulfonamides
The mechanism of Bacterial resistance to antimicrobial agents: A.Production of inactivator B.Decreased porins of bacterial outer membrane C.Modification of target sites D.Increased permeability of bacterial outer membrane E.Decreased efflux pump
The mechanism of Bacterial resistance to antimicrobial agents： A. Production of inactivator B. Decreased porins of bacterial outer membrane C. Modification of target sites D. Increased permeability of bacterial outer membrane E. Decreased efflux pump
一Lactam Antibiotics Penicillins Cephalosporins Monobactams Carbapenems Beta-Lactam inhibitors
β－Lactam Antibiotics Penicillins Cephalosporins Monobactams Carbapenems Beta-Lactam inhibitors