B-Lactam Antibiotics Penicillins 【Antibacterial activity】 Gram-positive coccus Gram-negative coccus Gram-positive bacilli Helicoids
β－Lactam Antibiotics 【 Antibacterial activity 】 Penicillins Gram-positive coccus Gram-negative coccus Gram-positive bacilli Helicoids
Semisynthetic penicillin Penicillinase-resistant penicillin(Oxacillin (1)They kill penicillinase-producing staphylococci (2)They can't kill Methicillin-resistant strains of Staphylococcus aureus (MRSA)
Semisynthetic penicillin Penicillinase-resistant penicillin( Oxacillin ) (1) They kill penicillinase-producing staphylococci (2) They can’t kill Methicillin-resistant strains of Staphylococcus aureus (MRSA)
Extended spectrum penicillins (Ampicillin) (1)They are more effective against gram-negative bacilli (2)They can not kill pseudomonas aeruginosa Antipseudomonal penicillins Carbenicillin Piperacillin
Extended spectrum penicillins (Ampicillin) (1)They are more effective against gram-negative bacilli (2)They can not kill pseudomonas aeruginosa Antipseudomonal penicillins Carbenicillin Piperacillin
Cephalosporins Feature First Second Third G+ ++ +十 + G- + 十十 十十十 Pseudomonas 一 + aeruginosa anaerobes 一 + + nephrotoxic +十 +
Cephalosporins Feature ＋＋＋ First Second Third G＋ ＋＋＋ ＋＋ ＋ G－ ＋ ＋＋ ＋＋＋ Pseudomonas aeruginosa － － ＋ anaerobes － ＋ ＋ nephrotoxic ＋＋ ＋ －
Other B-lactams antibiotics Carbapenems Imipenem cilastatin B-lactamase inhibitors Clavulanic acid +Amoxicillin
Imipenem + cilastatin Clavulanic acid + Amoxicillin Other β-lactams antibiotics Carbapenems β-lactamase inhibitors