03.1 Absorption d Absorption is the transfer of a drug from its site of administration to the blood stream. Gastrointestinal tract u Parenteral injection -im, S.c. Inhalation 日 Transdermal
3.1 Absorption Absorption is the transfer of a drug from its site of administration to the blood stream. Gastrointestinal tract Parenteral injection - i.m., s.c. Inhalation Transdermal
(1) Gastrointestinal tract Route: Oral Sublingual Rectal D Absorption sites Oral □口 Gastric Intestinal Rectal
(1) Gastrointestinal tract Route: Oral Sublingual Rectal Absorption sites: Oral Gastric Intestinal Rectal
Factors influencing absorption u blood flow to the absorption site u total surface area available for absorption u contact time at the absorption surface u physic-chemical properties of the drug 0 first-pass elimination
Factors influencing absorption: blood flow to the absorption site total surface area available for absorption contact time at the absorption surface physic-chemical properties of the drug first-pass elimination
0(2)Parenteral injection u intramuscular injection (im) subcutaneous injection(Sc) Determinants 0 Local blood flow, Solubility of the drug (3)Others Inhalation: Intranasal u Transdermal; Topical
(2) Parenteral injection intramuscular injection ( i.m. ) subcutaneous injection ( s.c. ) Determinants Local blood flow; Solubility of the drug (3) Others Inhalation; Intranasal; Transdermal; Topical
d3.2 Distribution d Drug distribution is the process by which a drug reversibly leaves the blood stream and enters the interstitium (extracellular fluid) and/or the cells of the tissues. o Blood flow-dependent phase of distribution Selective distribution Tissue-plasma balance: importance of measuring plasma concentration
3.2 Distribution Drug distribution is the process by which a drug reversibly leaves the blood stream and enters the interstitium (extracellular fluid) and / or the cells of the tissues. Blood flow-dependent phase of distribution Selective distribution Tissue-plasma balance: importance of measuring plasma concentration