Part 5 Antiatheroscleotic drugs
Normal bood cap of plaque B Loid.chore of pLague Endotenon C Atherosclerosis is a disorder in which lipid deposits accumulate on the lining of the blood vessels, eventually producing degenerative changes and obstruction of blood flow. Atherosclerosis is considered to be a major contributor in the development of heart disease
Plasma lipids Cholesterol free cholesterol(fo cholesterylester(ce) Triglyceride(tg) Phospholipid (Pl) Plasma lipoproteins Apoprotein(apo) ipoprotein(apoprotein+ lipids) Chylomicron(CM) Very low density lipoprotein (VLDL) Low density lipoprotein (LDL) Intermediate density lipoprotein (IDL) High density lipoprotein(HDL)
Dietary fat cholesterol - Chylomicrons LPL、 Chylomicron remnants INTESTINE FFA Adipose LPL tissue HL Bile acids FFA Peripheral tissues (with LDI receptors FFA ∵∵∵:了 LPL VLD IDL LDL LIVER receptors' i HL 的: Remnant, ApoE mediated 它: receptors ApoB mediated A poE mediated Lipid metabolism in the body
Drugs used in treatment of atherosclersis 1. Lipid- regulators(调血脂药) 2. Antioxidants(抗氧化药) 3. Polyunsaturated fatty acids PUFAS)(多不饱和脂肪酸) a 4. Protective agents for arterial endothelium(动脉内皮保护药)