Drugs affecting autacoids
Drugs affecting autacoids
A. Overview Autacoids: local hormones one of the requlator mechanisms in the body
• Autacoids: local hormones • one of the regulatory mechanisms in the body A. Overview
Electrical so neurotransmitter Secreting coll (neuron) Bood Target col Socrotngc hormone (endocrine cem Nontarget ce secretion (no receptors Electrical signal Blood Secreting ce Targot ce (neuron) neurohormone Nontarget secretion (no receptors
neurotrasmitter hormone secretion neurohormone secretion
gap junction secreting arachne旁分泌 autocrine自分泌 juxtacrine接触分泌
gap junction paracrine 旁分泌 autocrine 自分泌 juxtacrine接触分泌
A. Overview Autacoids: Histamine 5-Hydroxytryptamine(serotonin, 5-HT) Lipid-derived autocoids prostaglandins(PGs) Leukotrienes (LTs) Platelet activating factor(PAF) Vasoactive peptides Substance P(SP): Kinins(bradykinin, etc.) Angiotensins(AT); Natriuretic peptides(NP) Vasoactive intestinal peptide (VIP) Endothelins(En Calcitonin gene related peptide(CGRP) Nitric oxide(NO) Adenosine
A. Overview Autacoids: Histamine 5-Hydroxytryptamine (serotonin, 5-HT) Lipid-derived autocoids Prostaglandins (PGs) Leukotrienes (LTs) Platelet activating factor (PAF) Vasoactive peptides Substance P (SP)；Kinins (bradykinin, etc.) Angiotensins (AT)；Natriuretic peptides (NP) Vasoactive intestinal peptide (VIP) Endothelins (ET) Calcitonin gene related peptide (CGRP) Nitric oxide (NO) Adenosine