Chaper 20 Adrenoceptor Antagonists 1.areceptor antagonists 2.B receptor antagonists 3.a,B receptor antagonists
Chaper 20 Adrenoceptor Antagonists 1. αreceptor antagonists 2. receptor antagonists 3. α, receptor antagonists
AAdrenergic blockers have no effect on the actions of isoproterenol which is a pureβ agonist Pre treatment,:treatment Catecholamine Untreated with an“ya ontrol isoproterenol mm Ha 200 Epinephrine 200 Norepinephrine C-Adrenergic blockers reverse the vaso- constrictive action of epinephrine Epinephrine reversal(肾上腺素作用的圈转
Epinephrine reversal （肾上腺素作用的翻转）
1. at receptor antagonists I 1-1 a1 a receptor antagonists 0 Short-acting Phentolamine酚妥拉明 CH3 N——CH2 HO
1. receptor antagonists 1-1 1 , 2 receptor antagonists Short-acting Phentolamine 酚妥拉明 N N CH3 HO N CH2 H
1. at receptor antagonists 口1 Pharmacology 口(1) Vasodilatation u Blocking a,receptor I (2)Stimulating heart 口 Reflex; blocking a2 receptor NE release个 D 3) Cholinergic and histamine-like effects Contraction of GI smooth muscles, n个 0 Gastric acid secretion
1.1 Pharmacology (1) Vasodilatation Blocking 1 receptor (2) Stimulating heart Reflex；blocking 2 receptor ～NE release (3) Cholinergic and histamine-like effects Contraction of GI smooth muscles, Gastric acid secretion 1. receptor antagonists
1. at receptor antagonists 日1.2 Clinical uses o()Peripheral vascular diseases Acrocyanosis, Raynauds disease D (2) Local vasoconstrictor extravasation
1.2 Clinical uses (1) Peripheral vascular diseases Acrocyanosis, Raynaud’s disease (2) Local vasoconstrictor extravasation 1. receptor antagonists