un-ionized lipid- Simple H pKa form soluble diffusion Weak And /or acidanD/ortc→↑ Weak And /or ↓c今會會 bases And /or
pH pKa un-ionized form lipidsoluble Simple diffusion Weak acids Weak bases And / or And / or And / or And / or
B. Carrier(transporter)-mediated transport Transporter Receptor Channel Three types offunctional membrane proteins
Three types of functional membrane proteins. B. Carrier (transporter)-mediated transport
转运体 OOO OOOO OoO w ●● 电化学梯度 简单通道介导转运体介导 扩散的扩散的易化扩散 能量 被动转运 主动转运 Models of transmembrane transport across the lipid bilayer
Models of transmembrane transport across the lipid bilayer
02.2 Free and bound forms 0 Plasma protein binding Tissue/organ affini
2.2 Free and Bound Forms Plasma protein binding Tissue / organ affinity
u 3. Fate of the drug in the body u Absorption Distribution Metabolism u( Biotransformation) Drug Drug input g output Excretion ADME
3. Fate of the drug in the body Absorption Distribution Metabolism (Biotransformation) Excretion － ADME ADME