Antipyretic-Analgesic and Antinflammatory Drugs
Antipyretic-Analgesic and Antiinflammatory Drugs
A. General Pharmacological properties D 1. Inhibition ofprostaglandin synthesis inhibiting cyclooxygenase(COX,环氧酶 d decreasing the synthesis of PGs and TXA% I resulting antipyretic, analgesic, and anti inflammatory effects O non-steroidal anti-inflammatory drugs MAIDS,非甾体抗炎药)
A. General Pharmacological properties 1. Inhibition of prostaglandin synthesis inhibiting cyclooxygenase (COX，环氧酶), decreasing the synthesis of PGs and TXA2 , resulting antipyretic, analgesic, and antiinflammatory effects non-steroidal anti-inflammatory drugs (NSAIDs, 非甾体抗炎药）
Phospholipid 儿( from cell membran。), ∞5 corticosteroids mm)CO BradykInin Angiotensin Phospholipase A2 Arachidonic acid Cyclooxygenase NSAD8mm③ Pr。 stacyclIn(PGl2) PGG 2 ydro- PGE. 5-Lipoxygena PGF PGH Thromboxane a Dipyridamole 5-HPETE (see Chapter 20 Leukotrienes
膜磷脂 皮质斗 PLA2 激素 匚Ir-Dx花生四烯酸 炎性刺激 生理刺激}5c0X1c0x2 非甾体 抗炎药 中间体 PGE2 PGI2 炎症介质 TXA2
A. General Pharmacological properties 口2. Antipyretic effects u Inhibition of PGE, production in the hypothalamus induced by endogenous pyregens after pathological stimuli temperature I notes. symptomatic control only, not be indicated in all patients with fever u The effect on body temperature is different from that of chlorpromazine
2. Antipyretic effects Inhibition of PGE2 production in the hypothalamus induced by endogenous pyregens after pathological stimuli → temperature notes: symptomatic control only, not be indicated in all patients with fever. The effect on body temperature is different from that of chlorpromazine. A. General Pharmacological properties