Thyroid hormones and antithyroid drug
Thyroid hormones and antithyroid drugs
Metabolism of thyroid hormones 1. Uptake of iodide 2. Activation ofiodide(peroxidase) and iodination and coupling of tyrosine 3. Formation of thyroxine(t4)and triiodothyronine (l3) from iodotyrosine 4. Secretion of thyroidhormone (proteolytic enzymes) 5. Regulation by thyroidstimulating hormone( Tsai, T4, T3 of thy
Metabolism of thyroid hormones 1. Uptake of iodide 2. Activation of iodide (peroxidase), and iodination and coupling of tyrosine 3. Formation of thyroxine (T4 ) and triiodothyronine (T3 ) from iodotyrosine 4. Secretion of thyroid hormones (proteolytic enzymes) 5. Regulation by thyroid stimulating hormone (TSH),T4 , T3
Acute Circadian and psychosis pulsatile rhythms Severe Cold stress H Hypothalamus Somato @statin Corticoids Regulation of the secretion dopamine of thyroid hormones AP (feedback inhibition) TA.T TSH② Thyroid
Regulation of the secretion of thyroid hormones (feedback inhibition)
Pharmacology of thyroid hormones o 1. Normalizing growth and development u 2. Promoting body metabolism Body temperature; energy levels, ect. d 3. Enhancing sympathetic activity
1. Normalizing growth and development 2. Promoting body metabolism Body temperature; energy levels, ect. 3. Enhancing sympathetic activity Pharmacology of thyroid hormones
Clinical uses of thyroid hormones u 1. Treatment of hypothyroidism u Hypothyroidism 1. 8% of total population Incidence increases with age 2-3% of older women More common in females
1. Treatment of hypothyroidism Clinical uses of thyroid hormones Hypothyroidism 1.8% of total population. Incidence increases with age. 2-3% of older women. More common in females