Drugs affecting blood and blood-forming organs (作用于血液和造血系统药物 Tang Huifang(汤慧芳) Email:tanghuifang@zju.edu.cn
Drugs affecting blood and blood-forming organs (作用于血液和造血系统药物) Tang Huifang (汤慧芳) Email: tanghuifang@zju.edu.cn
General concept s affecting the ble gs lood and blood-forming organs Coagulation Anticoagulant drugs(抗凝血药) bleedin Antiplatelet drugs(抗血小板药) Fibrinolytic dr~ug(纤维蛋白溶解药) Hemostatic drugs(止血药) Blood cell Antianemic drugs(抗贫血药) growth Hematopoietic growth agents agents(促白细胞生长药 Blood volume Drugs for treatment of hypovolemia(血容量扩充剂)
Drugs affecting the blood and blood-forming organs Coagulationbleeding Anticoagulant drugs(抗凝血药) Antiplatelet drugs(抗血小板药) Fibrinolytic drugs(纤维蛋白溶解药) Hemostatic drugs(止血药) Blood cell growth Blood volume Antianemic drugs(抗贫血药) Hematopoietic growth agents agents (促白细胞生长药) • Drugs for treatment of hypovolemia (血容量扩充剂) General concept
Par1. Anticoagulants抗凝血药 凝血酶间接抑制剂: > Heparin(肝素) Low molecular weight heparin(低分子量肝素) > Fondaparinux(磺达肝癸钠) Oral direct Factor X inhibitors: Apixaban(阿派沙班)、 Rivaroxaban(利伐沙班 >凝血酶直接抑制剂( direct thrombin inhibitors,DTIs): ORAL DTIS: Dabigatran(达比加群) > Factor II inhibitor: Lepirudin(重组水蛭素/来匹卢定) desirudin(地西卢定)、 bivalirudin(比伐卢定)、 Argatroban (阿加曲班) Vitamin K antagonists: Coumarins香豆素类 Warfarin(华法林)、 dicoumarol(双香豆素) acenocoumarol(醋硝香豆素)
➢ 凝血酶间接抑制剂： ➢ Heparin（肝素） ➢ Low molecular weight heparin （低分子量肝素） ➢ Fondaparinux (磺达肝癸钠) ➢ Oral direct Factor X inhibitors：Apixaban （阿派沙班）、 Rivaroxaban(利伐沙班) ➢ 凝血酶直接抑制剂（direct thrombin inhibitors，DTIs)： ➢ ORAL DTIs: Dabigatran (达比加群) ➢ Factor II inhibitor: Lepirudin（重组水蛭素/来匹卢定）、 desirudin （地西卢定）、bivalirudin(比伐卢定)、Argatroban （阿加曲班） ➢ Vitamin K antagonists: Coumarins 香豆素类 Warfarin（华法林）、dicoumarol（双香豆素）、 acenocoumarol（醋硝香豆素） Part 1. Anticoagulants 抗凝血药
ANTICOGO山crcr山c Heparin(肝素) H2COSO3 CO0 HCOSO H2COSO3 o、KoH OH 0、K0 0、KQH O HOCH OH NHSO 3 OSo NHSO3 (or -SO3) N-acetyl N-sulfated Iduronic N-sulfated glucosamine Glucuronic glucosamine acid fucosamine 6-0-sulfate acid 3.6-0-disulfate 2-0-sulfate 6-0-sulfate MW of 530 kD(mean 12 kD) 化学:强酸性,具强负电荷(抗凝作用基础) 特效解毒剂:鱼精蛋白(碱性,强正电荷
Anticoagulant drugs MW of 5～30 kD(mean 12 kD). Heparin（肝素） 化学：强酸性，具强负电荷（抗凝作用基础） 特效解毒剂：鱼精蛋白（碱性，强正电荷）
Unraced Xa oD Ooooo Antiroman cOp ronⅪa、Ⅸa、Xa、Ⅻa Heparin accelerates inactivation of coagulation factors by antithrombin
• Heparin accelerates inactivation of coagulation factors by antithrombin. Ⅺa、Ⅸa、Ⅹa、Ⅻa