Part 5 Adrenoceptor Antagonists 1. at receptor antagonists 2. B receptor antagonists 3. a, B receptor antagonists
Part 5 Adrenoceptor Antagonists 1. receptor antagonists 2. receptor antagonists 3. , receptor antagonists
13585 12850 160 200 190/124 16082 175/110 13590 210 Epinephrine before phentolamine 12585 100/35 HR 210 Epinephrine after phentolamine Top: Effects of phentolamine, an areceptor-blocking drug, on blood pressure in an anesthetized dog. Epinephrine reversal is demonstrated by tracings showing the response to epinephrine before (middle)and after(bottom) phentolamine. All drugs given intravenously. (BP, blood pressure HR, heart rate. Epinephrine reversal(肾上腺素作用的翻转)
Epinephrine reversal （肾上腺素作用的翻转）
1. at receptor antagonists 0 1-1 a1, O, receptor antagonists a Short-acting Phentolamine酚妥拉明 CH3 N——CH2 HO
1. receptor antagonists 1-1 1 , 2 receptor antagonists Short-acting Phentolamine 酚妥拉明 N N CH3 HO N CH2 H
1. at receptor antagonists 口1.1 Pharmacolog u() Vasodilatation Blocking a, receptor; direct action u(2)Stimulating heart Reflex; blocking a, receptor w Ne release T 3)Cholinergic and histamine -like eflects Contraction of GI smooth muscles, 0 Gastric acid secretion T
1.1 Pharmacology (1) Vasodilatation Blocking 1 receptor; direct action (2) Stimulating heart Reflex；blocking 2 receptor ～NE release (3) Cholinergic and histamine-like effects Contraction of GI smooth muscles, Gastric acid secretion 1. receptor antagonists
1. at receptor antagonists 日1.2 Clinical uses u(1) Peripheral vascular diseases Acrocyanosis, Raynaud's disease d(2) Local vasoconstrictor extravasation
1.2 Clinical uses (1) Peripheral vascular diseases Acrocyanosis, Raynaud’s disease (2) Local vasoconstrictor extravasation 1. receptor antagonists