Chapter 30 Antiarrhythmic Drugs
Chapter 30 Antiarrhythmic Drugs
A normal rhythm Rs premature ventricular beat 人人人入人 C paroxysmal supraventricular tachycardia (PSVT) D atrial fibrillation arrhythmias E atrial flutter with variable Av conduction ++++++++++++++++ F atrial flutter with 1: 1 AV conduction G monomorphic ventricular tachycardia H Torsades de Pointes 从M从 √
arrhythmias
A. Electrophysiological basis of arrhythmias D 1. Normal cardiac electrophysiology I Excitability: ability to produce action potentials maximal diastolic potentials(MDP) thresold levels D Automaticity: pacemaker phase 4 slope D Conductivity conduction pathways, phase 0 amplitude
A. Electrophysiological basis of arrhythmias 1. Normal cardiac electrophysiology Excitability: ability to produce action potentials maximal diastolic potentials (MDP) thresold levels Automaticity: pacemaker phase 4 slope Conductivity: conduction pathways, phase 0 amplitude
inward outward 0 nase Na+ current Action Ca2+L-type current T-type potential transient ITO1 (4-AP-sensitive) and ion outward current To2 (Ca2+-activated) transport delayed rectifiers cI or lKp inward rectifier, Ik1 Fast response cell pacemaker current, If (…, see above Na*-Ca2+ exchange Na′,K+ ATPase
Action potential and ion transport Fast response cell
膜电位+20 mv 2 -20 RRP 40 SNP ERP 60 80 100 50 100150200250300350 Action potential and effective refractory period
Action potential and effective refractory period