Pharmacology of the nervous system Shi-Hong Zhang(张世红,PhD Dept of Pharmacology, School of Medicine, Zhejiang University shzhang713@zju.edu.cn
Pharmacology of the nervous system Shi-Hong Zhang (张世红), PhD Dept. of Pharmacology, School of Medicine, Zhejiang University shzhang713@zju.edu.cn 1
Pharmacology of efferent nervous system Cholinergic Pharmacology Adrenergic Pharmacology
• Cholinergic Pharmacology • Adrenergic Pharmacology Pharmacology of efferent nervous system 2
ACh ACh Parasympathetic Medulla Cardiac and smooth muscle land cells, nerve terminals ACh N Sympathetic ACh Sweat glands ACh N NE Sympathetic Cardiac and smooth muscle gland cells, nerve terminals Spinal cord ACh N Sympathetic Renal vascular smooth muscle ACh Epi. NE ACh Adrenal medulla Somatic Skeletal muscle Voluntary motor nerve Copyright @2006 by The McGraw-Hill Companies, Inc. All rights reserved
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NE synthesis in nerve terminals and turnover 1 SYNTHESIS OF NOREPINEPHRINE Hydroxylation of tyrosine In COOH 2 UPTAKE INTO STORAGE VESICLES Norepinephrine is protected hydroxylase om degradation in ahydrobiopterin, O,) vesicle is metabolise CH2C-COOH RELEASE OF L-DOPA 3 NEUROTRANSMITTER DopamIne DOPA decarboxylase cell membrane (Pyridoxal phosphate) CH, CH NH2 5 REMOVAL OF NOREPINEPHRINE Dopamine rapidly taken into neuron · Uptake Is inhibited by Dopamine B-hydroxylase cocaine and imipramine BINDING TO (Ascorbate, O, 4 RECEPTOR Postsynaptic receptor Inactive Urn● of neurotransmitter bolites SYNAPTIC Norepinephrine 6 METABOLISM SPACE Catecholamine Biosynthetic Pathway and oxidized by mo amine oxida INTRACELLULAR RESPONSE
NE synthesis in nerve terminals and turnover Catecholamine Biosynthetic Pathway 4
NH2 HO- CH2C-COOH Norepinephrine and Epinephrine H L-Tyrosine Synthesis in the Adrenal Medulla Tyrosine hydroxylase (Tetrahydrobiopterin, 0,) PNMT苯氨基乙醇N甲基转移酶 is located in the CH2C-COOH cytosol L-DOPA DBH多巴脱羧酶 is located in vesicles DOPA decarboxylase EPl is stored in vesicles (Pyridoxal phosphate) EPI(-80%) and NE (20%)are released into blood HO CH2 NH PNMT Dopamine B-hydroxylase NE)→NE—EPI→(EPI (Ascorbate, O2) H CHCH2 NH2 Norepinephrine Chromaffin cel enylethanolamine methyltransferase (s-adenosylmethionine CHCH2NHCH Epinephrine
Norepinephrine and Epinephrine Synthesis in the Adrenal Medulla - PNMT苯氨基乙醇N-甲基转移酶 is located in the cytosol - DBH 多巴脱羧酶 is located in vesicles - EPI is stored in vesicles. - EPI (~80%) and NE (~20%) are released into blood Chromaffin cell NE PNMT NE EPI EPI 5