Part 2 Pharmacokinetics 药物代谢动力学
Part 2 Pharmacokinetics 药物代谢动力学
Dose of drug administered sorption Drug concentration Distribution Drug in tissues in systemic circulation of distribution Elimination Kinetics Drug metabolized or excreted Models Drug concentration at site of action Parameters
Kinetics Models Parameters
0 2. Transport of Drug in the body A aqueous B lipid cell Ccarriers D endocytosis channels in the membranes (transporters exocytosis intercellular (into or out of junctions cells) Lumen Interstitium ●。 Mechanisms of drug permeation across cell membrane
2. Transport of Drug in the Body Mechanisms of drug permeation across cell membrane A. aqueous channels in the intercellular junctions B. lipid cell membranes C. carriers (transporters) (into or out of cells) D. endocytosis exocytosis
u 2.1 Transmembrane Transport of Drugs u(1) Non-carrier Transport Simple diffusion(简单扩散/单纯扩散) Filtration(滤过) A, aqueous B. lipid cell channels in the membranes tercellular unctions Ju Lumen
2.1 Transmembrane Transport of Drugs (1) Non-carrier Transport Simple diffusion（简单扩散/单纯扩散） Filtration（滤过）
d(2) Carrier-mediated Transport 口a. Active transport o Characteristics of active transport Involving specific carrier(transporter) o Energy-dependent o Saturability o Competition at same carrier Moving against concentration gradient (up-hill
(2) Carrier-mediated Transport a. Active transport Characteristics of active transport Involving specific carrier (transporter) Energy-dependent Saturability Competition at same carrier Moving against concentration gradient (up-hill)