To repair an error or damage First,Detect the errors or damage Second,Mend/repair the errors or lesions in a way to restore the original DNA sequence. 2025/5/15 7
2025/5/15 7 To repair an error or damage First, Detect the errors or damage Second, Mend/repair the errors or lesions in a way to restore the original DNA sequence
Questions to be addressed 1.How is the DNA mended rapidly enough to prevent errors from becoming set in the genetic material as mutation 2.How does the cell distinguish the parental strand from the daughter strand in repairing replication errors 2025/5/15
2025/5/15 8 Questions to be addressed 1. How is the DNA mended rapidly enough to prevent errors from becoming set in the genetic material as mutation 2. How does the cell distinguish the parental strand from the daughter strand in repairing replication errors
3.How does the cell restore the proper DNA sequence when the original sequence can no longer be read? 4.How does the cell deal with lesions that block replication? 2025/5/15 9
2025/5/15 9 3. How does the cell restore the proper DNA sequence when the original sequence can no longer be read? 4. How does the cell deal with lesions that block replication?
Section 1: The types and causes of DNA damage 2025/5/15 10
2025/5/15 10 Section 1: The types and causes of DNA damage
1.1 DNA undergoes damage spontaneously (自发的)from hydrolysis(水解)and deamination(脱氨基) Resulted from the action of water 2025/5/15 11
2025/5/15 11 1.1 DNA undergoes damage spontaneously (自发的) from hydrolysis (水解) and deamination (脱氨基) Resulted from the action of water