Moleculaogy Course CHAPTER 4:DNA damage and repair(DNA损伤与修复) Help l!my DNA is broken teaching hours 2025/5/15
2025/5/15 2 CHAPTER 4: DNA damage and repair（DNA损伤与修复） •Molecular Biology Course 4 teaching hours
Outline: Section 1:The types and causes of DNA damage(DNA损伤的类型及原因) Section 2:The repair mechanisms of DNA damage(DNA损伤的修复机制) 2025/5/15 3
2025/5/15 3 Outline: Section 1：The types and causes of DNA damage (DNA损伤的类型及原因) Section 2: The repair mechanisms of DNA damage (DNA损伤的修复机制)
■Key points(重点掌握)： The types and causes of DNA damage (DNA损伤的类型及原因) The repair mechanisms of DNA damage (DNA损伤的修复机制) 2025/5/15 4
2025/5/15 4 ◼ Key points (重点掌握)： The types and causes of DNA damage (DNA损伤的类型及原因) The repair mechanisms of DNA damage (DNA损伤的修复机制)
The consequence of high rates of mutation Mutation in germ cell(生殖细胞)would destroy the species ■Mutation in somatic cell(体细胞)would destroy the individual. Maintenance of the correctness of the DNA sequence is definitely crucial for living organisms. 2025/5/15 5
2025/5/15 5 The consequence of high rates of mutation ◼ Mutation in germ cell (生殖细胞) would destroy the species ◼ Mutation in somatic cell (体细胞) would destroy the individual. Maintenance of the correctness of the DNA sequence is definitely crucial for living organisms
Two important sources for mutation (unavoidable) Inaccuracy in DNA replication-Errors (错误) ■ Chemical and radiant damage to the genetic material(environment) 2025/5/15 6
2025/5/15 6 Two important sources for mutation (unavoidable) ◼ Inaccuracy in DNA replication- Errors (错误) ◼ Chemical and radiant damage to the genetic material (environment)