Molecular Biology course dhapter 8 The Hot Topics in Genomics and Post-Genome Era 2025/5/15
2025/5/15 1 Chapter 8 The Hot Topics in Genomics and Post-Genome Era •Molecular Biology Course
Outline Topic 1 Genome and genomics Topic 2 Proteomics Topic 3 Metabolomics Topic 4 Human Microbiome Project(HMP) 2025/5/15 2
2025/5/15 2 Topic 1 Genome and genomics Topic 2 Proteomics Topic 3 Metabolomics Topic 4 Human Microbiome Project (HMP) Outline
Key points重点掌握： The progress and importance of the HGP(HGP 划的进展及重要意义)： Shotgun sequencing technology(鸟枪法序列分析技 术)； The content of HapMap plan(HapMap计划内容)； ■人类元基因组计划 the concept and progress of transcriptomics, proteomics and metabolomics(转录组学、蛋白组学 及代谢组学概念及进展)。 2025/5/15 3
2025/5/15 3 Key points 重点掌握： The progress and importance of the HGP( HGP 计 划的进展及重要意义)； Shotgun sequencing technology(鸟枪法序列分析技 术)； The content of HapMap plan (HapMap计划内容) ； 人类元基因组计划 the concept and progress of transcriptomics, proteomics and metabolomics( 转录组学、蛋白组学 及代谢组学概念及进展)
The studies on gene are the main line of life sciences in the 20th century 基因研究是20世纪生命科学的主线 In the first half of the 20th century as represented by genetics,the main outcomes of the life sciences include law of segregation law of independent assortment,law of linkage and crossing over,chemical properties of gene,DNA double helix structure,etc. 20世纪的上半叶，以遗传学为代表，生命科学通过 对基因分离、独立分配、莲锁及化学属性等的研 究L最這以作为遗传信息载体的DNA双螺旋结构 的提出耑苦捷。 2025/5/15 4
2025/5/15 4 The studies on gene are the main line of life sciences in the 20th century 基因研究是20世纪生命科学的主线 ★ In the first half of the 20th century , as represented by genetics, the main outcomes of the life sciences include law of segregation , law of independent assortment , law of linkage and crossing over , chemical properties of gene, DNA double helix structure, etc. 20世纪的上半叶，以遗传学为代表，生命科学通过 对基因分离、独立分配、连锁及化学属性等的研 究，最后以作为遗传信息载体的DNA双螺旋结构 的提出而告捷
In the second half of the 20th century,as represented by molecular biology,the life sciences reveal the mechanisms of DNA replication,transcription,translation and analysis the genetic codes and put forward “the central dogma”. 20世纪下半叶，以分子生物学为代表，生命科学通 过对基因复制 转绿 翻译及传密码的公析与 破锋最终以统二生命世客层，生命料学各 分支的“中心法则”的问世而集成。 2025/5/15 5
2025/5/15 5 ★ In the second half of the 20th century, as represented by molecular biology, the life sciences reveal the mechanisms of DNA replication, transcription, translation and analysis the genetic codes and put forward “the central dogma”. 20世纪下半叶，以分子生物学为代表，生命科学通 过对基因复制、转录、翻译及遗传密码的分析与 破译，最终以统一生命世界各层次，生命科学各 分支的“中心法则”的问世而集成