Section 6 Synthetic antimicrobial agents Yun-Bi Lu, PhD 卢韵碧 Dept of Pharmacology, School of Medicine, Zhejiang University yunbi@zju.edu.cn
Synthetic antimicrobial agents Section 6 Yun-Bi Lu, PhD 卢韵碧 Dept. of Pharmacology, School of Medicine, Zhejiang University yunbi@zju.edu.cn
Contents Quinolones(喳诺酮粪) Sulfonamides(磺胺类) Other Synthetic antimicrobial Trimethoprim(甲氧苄) Nitrofurans(确基失喃类
• Quinolones ( 喹诺酮类) • Sulfonamides ( 磺胺类) • Other Synthetic antimicrobial Trimethoprim (甲氧苄啶) Nitrofurans (硝基呋喃类) Contents
Contents Quinolones(诺酮类) Sulfonamides(嘴胺类) Other Synthetic antimicrobial Trimethoprim(甲氧苄咬) Nitrofurans(硝基央喃类)
• Quinolones ( 喹诺酮类) • Sulfonamides ( 磺胺类) • Other Synthetic antimicrobial Trimethoprim (甲氧苄啶) Nitrofurans (硝基呋喃类) Contents
From chloroquine to nalidixic acid nalidixic acid CH o chloroquine CH C? 1939 心1962 1958° C2H5 7-chloroquinoline (synthesis intermediate found to display antibacterial activity)
From chloroquine to nalidixic acid
喹诺酮类( Quinolones) Generation Example time Nalidixic acid纂啶酸1962 2 Pipemidic acid呲哌酸1973 3 Norfloxacin诺氟沙星 4 Clinafloxacin克林泱星1990s
Generation Example time 1 Nalidixic acid 萘啶酸 1962 2 Pipemidic acid 吡哌酸 1973 3 Norfloxacin 诺氟沙星 4 Clinfloxacin 克林沙星 1990’s 喹诺酮类 (Quinolones)