Introduction to Anti-inflammatory Drugs Peiping Zhang Department of Pharmacology Zhejiang University School of Medicine 2012.10
Introduction to Anti-inflammatory Drugs Weiping Zhang Department of Pharmacology Zhejiang University School of Medicine 2012.10
Promotes Mast cell swelling Bradykinin o Substance P Prostaglandins Histamine Noxious signal Dorsal root Blood Noxious essel Substance P Spinal cord Peripheral mechanisms of pain
Peripheral mechanisms of pain
Classification of anti-inflammatory drugs (1)non-steroid anti-inflammatory drugs (NSAIDs) (Antipyretic-Analgesic and Anti-inflammatory Drugs) 解热-镇痛-抗炎药 eg aspirin, acetaminophen, indomethacin, COX inhibitor, ibuprofen (2)Steroid anti-inflammatory drugs glucocorticoids: eg. dexamethasone (3)5-LOX inhibitors and leukotriene receptor antagonists Zafirlukast. zileuton
Classification of anti-inflammatory drugs (1) non-steroid anti-inflammatory drugs (NSAIDs) (Antipyretic-Analgesic and Anti-inflammatory Drugs) 解热-镇痛-抗炎药 eg. aspirin, acetaminophen, indomethacin, COX inhibitor, ibuprofen (2) Steroid anti-inflammatory drugs glucocorticoids: eg. dexamethasone (3) 5-LOX inhibitors and leukotriene receptor antagonists Zafirlukast, zileuton
1. The classification of nsaids 表203非甾体抗炎药的分类 化学分类 代表药物 苯胺类 对乙酰氨基酚 吡唑酮类 保泰松 甲酸类水杨酸类 阿司匹林 乙酸类 吲哚乙酸类 吲哚美辛 茚乙酸类 林酸 萘乙酸类 萘丁美酮 有机酸类 羧酸类 邻氨苯乙酸类 双氯芬酸 苯乙酸类 芬布芬 丙酸类 苯丙酸类 布洛芬 萘丙酸类 萘普生 吡罗昔康 酸类 苯并噻嗪类 美洛昔康 其他 尼美舒利 NSAIDs are just that- drugs that act to relieve inflammation, but are not structurally related to the corticosteroids
NSAIDs are just that - drugs that act to relieve inflammation, but are not structurally related to the corticosteroids 1. The classification of NSAIDs
2. The mechanisms of nsaids Arachidonic acid esterified in membrane phospholipids Free radicals Diverse physical, chemical inflammatory and mitogenic stimuli Phospholipase A2 eicosatrienoic acids Isoprostanes EETS 9865 COOH Cytochrome P450 AA(204csD5,8,1114) 20 11121415 19 Lipoxygenases Cyclooxygenases (LOX) HETEs Prostaglandins Leukotrienes Prostacyclin 7 Prostanoids Lipoxins Thromboxane
2. The mechanisms of NSAIDs