Pharmacology for Pain and analgesia Dept of Pharmacology Shi-Hong Zhang(张世红 shzhang713@zju.edu.cn SaperbPlanetcom
Pharmacology for Pain and Analgesia Dept of Pharmacology Shi-Hong Zhang (张世红) shzhang713@zju.edu.cn
What is pain An unpleasant sensory or emotional experience associated with actual or potential tissue damage or described in terms of such damage. Pain is always subjective. Each individual learns the application of the word through experiences related to injury in early life. It is unquestionably a sensation in a part of the body but it is also unpleasant and therefore also an emotional experience. Many people report pain in the absence of tissue damage or any likely pathophysiological cause; usually this happens for psychological reasons. There is no way to distinguish their experience from that due to tissue damage if we take this subjective report IASP Pain1979(6)249-252
What is pain An unpleasant sensory or emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Pain is always subjective. Each individual learns the application of the word through experiences related to injury in early life. It is unquestionably a sensation in a part of the body, but it is also unpleasant, and therefore also an emotional experience. Many people report pain in the absence of tissue damage or any likely pathophysiological cause; usually this happens for psychological reasons. There is no way to distinguish their experience from that due to tissue damage, if we take this subjective report…… IASP. Pain 1979(6)249-252
Physiology of Pain Pain sensation First pain: shal irp, pricking, well defined. As fibers Second pain: dull, aching, poorly localized, c fibers
Physiology of Pain Pain sensation First pain：sharp, pricking, well defined，A fibers Second pain：dull, aching, poorly localized, C fibers
Pain signals to brain stem and brain ightly myelinate As fibres Large cell (through secondary To supraspinal ain-projection targets neurons Heavily DRG myelinated Aβ fibres Dorsal Small cell bodies Unmyelinated Fibres neurons Ventral Ventral projection fibres Pain signals to spinal cord (through primary afferents Normal acute pain Milligan et al 2009
Milligan et al, 2009
Chronic pain Types and reasons Neuropathic pain Inflammatory pain Bone cancer pain Fibromyalgia igraine Psychogenic pain
Types and reasons Neuropathic pain Inflammatory pain Bone cancer pain Fibromyalgia Migraine Psychogenic pain Chronic Pain