浙孚 ZheJiang University Antianginal druas 抗心绞痛药物 Huifang Tang Department of pharmacology Zhejiang Universiti School of Medicin tanghuifang⊙z
Antianginal drugs 抗心绞痛药物 Huifang Tang Department of pharmacology Zhejiang University School of Medicine tanghuifang@zju.edu.cn
1. Overview 2. Antianginal drugs Organic nitrates β-b| ockers Calcium channel blockers 3. Combination of antianginal drugs
1. Overview 2. Antianginal drugs - Organic nitrates - β-blockers - Calcium channel blockers 3. Combination of antianginal drugs
Overview: Angina pectoris心绞痛 The name angina pectoris denotes chest pain caused by accumulation of metabolites resulting from myocardial ischemia 临床表现:阵发性的胸骨后压榨性疼痛并向左 上肢放射。 most common cause of angina is atheromatous obstruction of the large coronary vessels(coronary artery disease, CAD)
Overview: Angina pectoris 心绞痛 The name angina pectoris denotes chest pain caused by accumulation of metabolites resulting from myocardial ischemia. • 临床表现：阵发性的胸骨后压榨性疼痛并向左 上肢放射。 • most common cause of angina is atheromatous obstruction of the large coronary vessels (coronary artery disease, CAD). 3
Symptoms 16%7% 40% 4% 46% 23 Sudden, uncomfortable pressure, fullness squeezing or severe subsTernal pain, radiaTing to the left arm shoulders neck, etc
Sudden, uncomfortable pressure, fullness, squeezing or severe substernal pain, radiating to the left arm, shoulders, neck, etc. Symptoms:
Classification of angina pectoris Stable angina pectoris Unstable angina pectoris( Effort angina Caused initial onset type(初发型)( ( classic angina) atherosclerosis accelerated typer(恶化型 plaque and/or thrombus spontaneous type(自发型) formation angina at rest卧位型) Variant angina(变异型) Caused by spontaneous spasm of coronary arteries Mixed angina pectoris
• Stable angina pectoris • Unstable angina pectoris – initial onset type(初发型) – accelerated type(恶化型) – spontaneous type(自发型) • angina at rest(卧位型) • Variant angina （变异型） • Mixed angina pectoris Caused by atherosclerosis plaque and/or thrombus formation Caused by spontaneous spasm of coronary arteries Classification of angina pectoris: 5 Effort angina （classic angina）