Basic clinical Pharmacology Drugs affecting reproductive system
Drugs affecting reproductive system Basic & Clinical Pharmacology
Drugs affecting male reproductive system Classification A Androgens and antiandrogens 1. testosterone(睾酮) 2. methyltestosterone(甲睾酮) orally effective 3. testosterone propionate(丙酸睾丸素) most commonly used 4. mesterolone(甲二氢睾酮,美睾酮) 5 fluoxymesterone(氟甲睾酮 6 testosterone phenyl- acetate(苯乙酸睾丸素) 7.tristeronum compositum testosterone propionate 25mg estradiol benzoate(苯甲酸雌二醇)1.25mg progesterone 12.5mg,im B Antiandrogens cyproterone(环丙孕酮,环甲氯地孕酮 C. Drugs used to treat erectile dysfunction sidenafil(西地那非)
Classification A. Androgens and antiandrogens 1. testosterone(睾酮 ) 2. methyltestosterone(甲睾酮) orally effective 3. testosterone propionate (丙酸睾丸素) most commonly used 4. mesterolone (甲二氢睾酮，美睾酮) 5.fluoxymesterone(氟甲睾酮) 6.testosterone phenyl-acetate(苯乙酸睾丸素) 7.tristeronum compositum testosterone propionate 25mg estradiol benzoate(苯甲酸雌二醇) 1.25mg progesterone 12.5mg，i.m B. Antiandrogens • cyproterone(环丙孕酮，环甲氯地孕酮) C. Drugs used to treat erectile dysfunction • sidenafil(西地那非) Drugs affecting male reproductive system
A. Androgens and antiandrogens Androgens OH 0-C-( CH2)9-CH3 Testosterone睾酮 Testosterone undecanoate十一酸睾酮 OC—CH2CH: 一一“ Nandrolone phenylpropionate 苯丙酸诺龙
A. Androgens and antiandrogens Androgens Testosterone 睾酮 Testosterone undecanoate 十一酸睾酮 O O H CH2CH2 O C Nandrolone phenylpropionate 苯丙酸诺龙
26 Mineralo cortic oids (21 carbons) 27 Cholesterol Aldosterone Cholesterol side-chain Aldosterone lavage enzyme synthas Deoxy- Progesterone corticosterone Corticosterone Pregnenolone 17a-hydroxyla n 17a-hycroxy 1a-hydroxy e pregnene progesterone OH 0 11-deoxycartisol Cortisol 1.20ba5g Glucocorticoids (21 carbons) Dehycoepi- Andtoste-3 strone androsterone redone 17阝-HsD Estriol Adrostenedd Testosterone Estrada 5a-reductase Cellular location of enzymes Mitochondria Dihydrotestosterone Smooth endoplasmic reticulum
A. Androgens and antiandrogens Pharmacological effects (1)Development of the male sexual apparatus and secondary sex characteristics (2) Necessary for normal spermatogenesis(精子发生) (3)Increasing protein anabolism (4) Promoting growth of blood cells in bone marrow, especially for red blood cells(EPO D) (other effects: immune regulation, antinflammation effects, cvs effects
Pharmacological effects (1) Development of the male sexual apparatus and secondary sex characteristics (2) Necessary for normal spermatogenesis (精子发生) (3) Increasing protein anabolism (4) Promoting growth of blood cells in bone marrow, especially for red blood cells (EPO ) (5)Other effects: immune regulation, antiinflammation effects,CVS effects A. Androgens and antiandrogens