Phospholipid I(from cell membrane) Corticosteroids>OI@ Bradykinin ) Angiotensin ospnollpase A2 PAF Arachidonic acid Cyclooxygenase Lipid-derived NSAIDs mmm>O autacoids and antagonists related drugs ProstacyclIn(PGL) PGG2 Hydro- peroxidase inhibitors PGE PGF PGH →5 Lipoxygenase 6 Thromboxane A Dipyridamole 5-HPETE Leukotrienes◆…" antagonists
antagonists inhibitors PAF antagonists Lipid-derived autacoids and related drugs
Chemical Arachidonic Acid ESSENTIAL ESTERIFIED ACID and Mechanical COOH Dexamethasone FATTY ACID IN CELL LIPID Cytokines IN DIET e.g, Phospholipids Activation of Growth Factors of Cell Membrane Ph Endotoxin Cyclooxygenase-2 False substrates: e. g see Antinflammatory ^ Figure 26-2 58,11,14 Eicosa e.g., Aspirin and TO coo tetraenoic Acid Indomethacin Dazoxiben cooH CoOH HOOC PGH2 Thromboxane DOH PGG operas Isomerase PGI2 COOH cooH Active HYDROLYSIS PGE 20 PGDHI PGO+ SucrASE metabolites MOXIDATION L, REDUCTION 9a, 11B. PGF2 XIAN 2(0A1w u OX:DATON TION OXIDATION M OXIDATION HYDROLYSA Urinary COOH CoOH O Y PGD-M wo CoOH Prostaglandins(PGs) 11-Dehydro-0 C230m TXB2
Prostaglandins (PGs)
Lipoxygenase +/ATP Arachidonic Acid (cytosolic COOH 5-Lipoxygenase 12-Lipoxygenase (membrane-bound) COOH OOH COOH COOH 12-HETE 12-HPETE 5-HPETE 5-HETE LTA Synthase activity of 5-Lipoxygenase CgHrOH142o03 LTA Hydrolase COOH Leukotriene B4 LTB ChIl Leukotriene A (LTA Leukotriene C4 Synthase cOo cOoH .ShIr H s ,ChUl peptidase GLute Leukotriene E, cys Leukotriene D4 Cys-cl transpeptidase Leukotriene C 9ye-Gy (LTE LTD (LTCA Leukotrienes (LTs): LTB LTC4, LTD4, LTE4
Leukotrienes (LTs): LTB4 ; LTC4 , LTD4 , LTE4