Na* channels Nat Channels K+ Channels K+ channels N C X Ca2+ Channels Ca+ channels Channel structure N
Na+ Channels K+ Channels Ca2+ Channels
A. General properties of ion channels in CVS D Functional regulation of voltage-gated ion channels Activation(open) u Inactivation(close)
A. General properties of ion channels in CVS Functional regulation of voltage-gated ion channels Activation (open) Inactivation (close)
Closed A Conformational change in one region Gating modes of B General structural change on channeis Closed pore Blocking particle
Gating modes of ion channels
u Ligand-gated ion channels Reversible antagonist Irreversible antagonist Exogenous Endogenous regulator agonist En Extracellular Cytoplasmic Reversible reaction Irreversible reaction
Ligand-gated ion channels