抗生素的生产 概述 抗生素的分类 抗生素的应用 半合成抗生素 青霉素的生产和提取工艺
抗生素的生产 概述 抗生素的分类 抗生素的应用 半合成抗生素 青霉素的生产和提取工艺
抗生素的生产 定义：是生物在其生命过程中产生的，并在低浓度下 有选择性地抑制或杀灭其它微生物或肿瘤细胞的有机 物质。Microbial Products,effective at low concentrations,which have the ability to kill or inhibit the growth of certain micro-organisms. History: 19世纪70年代，法国Pasteur,发现有些微生物可以抑制 炭疽杆菌，提出了利用微生物抑制另一种微生物的现 象来治疗一些感染性疾病。1928年， 概述
抗生素的生产 定义：是生物在其生命过程中产生的，并在低浓度下 有选择性地抑制或杀灭其它微生物或肿瘤细胞的有机 物质。Microbial Products,effective at low concentrations,which have the ability to kill or inhibit the growth of certain micro-organisms. History: 19世纪70年代，法国Pasteur,发现有些微生物可以抑制 炭疽杆菌，提出了利用微生物抑制另一种微生物的现 象来治疗一些感染性疾病。1928年， 概述
In 1928 Scottish bacteriologist Alexander Fleming reported the antibacterial action of cultures of a Penicillium species He observed that Penicillium notatum killed some of his Staph. aureus culture dishes Discovery by accident? Culture dishes contaminated when left out for two weeks while Fleming was on holiday, instead of being incubated
In 1928 Scottish bacteriologist Alexander Fleming reported the antibacterial action of cultures of a Penicillium species He observed that Penicillium notatum killed some of his Staph. aureus culture dishes Discovery by accident? Culture dishes contaminated when left out for two weeks while Fleming was on holiday, instead of being incubated
Fleming noticed that the substance secreted was an inhibitor of many bacterial species He published a paper on the active ingredient which he called ‘penicillin’. This was the first demonstration that a substance produced by micro-org’s could inhibit or kill other microbes Fleming could not isolate penicillin. 10 yrs later scientists Florey and Chain successfully isolated penicillin. 1943-1945，scale-up production of pencillium. By 1945,enough penicillin was produced to treat 7 million per year
Fleming noticed that the substance secreted was an inhibitor of many bacterial species He published a paper on the active ingredient which he called ‘penicillin’. This was the first demonstration that a substance produced by micro-org’s could inhibit or kill other microbes Fleming could not isolate penicillin. 10 yrs later scientists Florey and Chain successfully isolated penicillin. 1943-1945，scale-up production of pencillium. By 1945,enough penicillin was produced to treat 7 million per year
Discoverer of penicillin Born into a farming family in Scotland, moved to London at 13 Awarded Scholarship to study medicine Alexander Fleming
Discoverer of penicillin Born into a farming family in Scotland, moved to London at 13 Awarded Scholarship to study medicine Alexander Fleming