ACEs and arBs ACEIs 100 Clinical uses. 80 E Placebo ◆cHF 低剂量即延缓逆转肥厚和晕 Enalapril 重构 增加运动耐量 -降低病死率 036912 ◆高血压 Time( Months)
ACEIs Clinical uses: CHF - 低剂量即延缓/逆转肥厚和 重构 - 增加运动耐量 - 降低病死率 高血压 ACEIs and ARBs 16
ACEIs and arbs ACEIs Adverse reactions 低血压(首剂现象) 肾脏损害(肾动脉硬化患者) 干咳和血管性水肿(缓激肽刺激作用) 高钾血症(醛固酮抑制) 皮疹和味觉改变(-SH相关) 胎毒性(妊娠中后期, pregnancy category D) cNS和G系统的不良反应
ACEIs and ARBs ACEIs Adverse reactions 低血压 (首剂现象) 肾脏损害 (肾动脉硬化患者) 干咳和血管性水肿(缓激肽刺激作用) 高钾血症 (醛固酮抑制) 皮疹和味觉改变 (-SH相关) 胎毒性 (妊娠中后期，pregnancy category D) CNS 和 GI 系统的不良反应
ACEIs and arbs ACEIs Contraindications 肾动脉硬化( pressure-dependent kidney perfusion in these patients) 孕妇和哺乳期妇女
ACEIs Contraindications 肾动脉硬化(pressure-dependent kidney perfusion in these patients) 孕妇和哺乳期妇女 ACEIs and ARBs
ACEs and arBs ARBS Compared with ACEIs: o Block actions of angiotensin ll directly No influence on bradykinin metabolism Protect renal function Used for CHF and hypertension ◆ Less adverse effects
ARBS Compared with ACEIs: Block actions of angiotensin II directly No influence on bradykinin metabolism Protect renal function Used for CHF and hypertension Less adverse effects ACEIs and ARBs 19