1. at receptor antagonists D 1-2 O, receptor antagonists o prazosin, for hypertension treatment D 1-3 a, receptor antagonists yohimbine
1-2 1 receptor antagonists prazosin, for hypertension treatment 1-3 2 receptor antagonists yohimbine 1. receptor antagonists
2. B receptor antagonists 日21ADME u First-pass elimination, D lower bioavailability: propranolol o Hepatic metabolism and renal excretion hepatic and renal functions alter the effects of the drugs and result in large individual variation O So, dose individualization is necessary
2.1 ADME First-pass elimination, lower bioavailability: propranolol Hepatic metabolism and renal excretion, hepatic and renal functions alter the effects of the drugs and result in large individual variation So, dose individualization is necessary. 2. receptor antagonists