Narcotic Antitussives Other narcotic antitussives Dihydrocodeine(双氢可待因) as Drotebanol(羟蒂巴酚) 6 Pholcodine(福尔可定)
Other narcotic antitussives: Dihydrocodeine（双氢可待因）; Drotebanol（羟蒂巴酚）; Pholcodine（福尔可定） Narcotic Antitussives
Narcotic Antitussives Drotebanol(Oxymethebanol) 羟蒂巴酚 A morphinan derivative that acts as an opiod agonist Cough suppressant effects OH around 10x more potent than codeine Analgesic effects: several times OH stronger than codeine, but weaker than morphine
Drotebanol (Oxymethebanol) 羟蒂巴酚 A morphinan derivative that acts as an opiod agonist Narcotic Antitussives ◆cough suppressant effects : around 10x more potent than codeine. ◆analgesic effects : several times stronger than codeine, but weaker than morphine
Narcotic Antitussives Pholcodine(福尔可定) an opioid cough suppressant mild sedative effect little or no analgesic effects lower potential for d dependence H
Pholcodine（福尔可定） Narcotic Antitussives an opioid cough suppressant mild sedative effect little or no analgesic effects lower potential for dependence
Non-Narcotic Antitussives Dextromethorphan(右美沙芬,DXM) CHa I3C0 N—CH3 N—CH HOr . Dextromethorphan Codeine
Dextromethorphan(右美沙芬， DXM) O N CH3 HO H3CO Dextromethorphan Codeine Non-Narcotic Antitussives
Metabolism of dextromethorphan CY3PA CY2PD6 HO 3-methoxymorphinan Dextromethorphan (3-甲氧基吗啡喃) H CY2PD6 CY3PA 3-hydroxymorphinan H (3-羟基吗啡南) CH3 dextrorphan(右啡烷) Antitussive drugs--past, present, and future. -Pharmacol Rev. 2014 Mar 26: 66(2): 468-512
Antitussive drugs--past, present, and future. Pharmacol Rev. 2014 Mar 26;66(2):468-512. Metabolism of dextromethorphan. dextrorphan(右啡烷) 3-methoxymorphinan (3-甲氧基吗啡喃) 3-hydroxymorphinan (3-羟基吗啡南)