Pc八、所的印5551535251504984184 43 42 41 PC2 78910111213716少如98 C OH 39 S-S A chal 37 PHE GLU ER LEU TYR GLM UGSN SP 36 VAL c THR SER 56 35 s-S 5 LEU 6901121311516171819202122329、录以 6 S SER chain THR ALA TYR PC3 LEU VAL Structure of insulin
A. Insulin and its enhancers Insulin 1. Pharmacological effects ()Carbohydrate metabolism: reducing blood glucose levels by gycogenolysis t, glycogen synthesis t, gluconeogenesis l(ketone ladies l) (2)lipid metabolism: fat synthesis T, lipolysis t, plasma free fatty acidsψ (3) Protein metabolism: active transport of amino acids incorporation of amino acids into protein t, protein catabolism (4)Mechanism of insulin actions Interacting with insulin receptor
INSULIN fatty acids glucose amino acids triglycerides glycogen protei n adipose tissue liver muscle fatty acids stimulated by insulin inhibited by insulin I increased by feeding increased by fasting and in diabetes
330. B1 SS S receptor binding face A21 Structure of insulin
Insulin insulin Sites of glycosylation S-S S-S S-S IS-S Cell membrane ①P P①①P ATP、( inase ADP ATP、( Kinase)yADP phosphorylated protein