日Reps n channe ETC Parietal cell ITC acetycholine umina membrane M ATP histamine H →cAMP EDEH, K-ATPaseL> Gastric lumen gastrin Ca on channels call bonbon rane Gastric acid secretion and regulation
A. Drugs used for peptic ulcers 1. Antacids 2. Drugs affecting gastric acid secretion Muscarinic receptor antagonists H 2 receptor antagonists H+-K+-ATPase inhibitors(proton pump inhibitors) Gastrin receptor antagonists 3. Mucosal protective drugs 4. Antimicrobial drugs(Helicobacter pylori)
A. Drugs used for peptic ulcers Features of antacids Basic substances that reduce gastric acidity by neutralizing HCl o The hydroxide is the most common base but trisilicate carbonate and bicarbonate ions are also used aLuminium, magnesium or sodium
GASTRIN muscarinIc antagonists RsoH N M K+ K+ YACh C CCK antagonists CCK2l K HIST HIST-H H+ K M2ECL cell CAMP-dependent ATPase X -proton pump AC NSAIDS EP. c pathway inhibitors parietal cell H* X-antacids fatty- PG2 misoprostol bismuth metronidazole muscarinIc X-tetracyo antagonists clarithromycin H. pylor 80点 amoxicillin mucus ACh . Sucralfate protection carbonoxolon pirenzepine ACh superficial epithelial cell HCO Mucous Gastric Layer Lumen H7 h 2
A. Drugs used for peptic ulcers Drugs affecting gastric acid secretion Muscarinic receptor antagonists Pirenzepine哌仑西平 N COCH - CH3
N N N COCH2 CH3 H O N N---