Massachusetts Institute of Technology yE图 Harvard medical school Brigham and women's hospital VA Boston Healthcare System 2.79J3.96JBE,441/HST522J TISSUE ENGINEERING STEM CELLS I.V.Yannas, Ph. D, and M. Spector, Ph D
Massachusetts In Massachusetts Institute of Technology stitute of Technology Harvard Medical School Harvard Medical School Brigham and Wo Brigham and Women’s Hospital men’s Hospital VA Boston Healthcare System VA Boston Healthcare System 2.79J/3.96J/BE.441/HST522J 2.79J/3.96J/BE.441/HST522J TISSUE ENGINEERING: TISSUE ENGINEERING: STEM CELLS STEM CELLS I.V. Yannas, Ph.D. and M. Spector, Ph.D. I.V. Yannas, Ph.D. and M. Spector, Ph.D
CELLS FOR TISSUE ENGINEERINGREGENERATIVE MEDICINE ° Autologous Differentiated parenchymal cells of same or other tissue type Stem cells(adult) Allogeneic Same as above Fetal stem cells Embryonic stem cells
CELLS FOR TISSUE CELLS FOR TISSUE ENGINEERING/REGENERATIVE MEDICINE ENGINEERING/REGENERATIVE MEDICINE • Autologous Autologous –Differentiated parenchymal cells of same or Differentiated parenchymal cells of same or other tissue type other tissue type – Stem cells (adult) Stem cells (adult) • Allogeneic Allogeneic – Same as above Same as above –Fetal stem cells Fetal stem cells –Embryonic stem cells Embryonic stem cells
WHAT ARE STEM CELLS? Cells with the capacity for unlimited or prolonged self-renewal. Cells that can produce at least one type of highly differentiated descendant
WHAT ARE STEM CELLS? WHAT ARE STEM CELLS? • Cells with the capacity for unlimited or Cells with the capacity for unlimited or prolonged self prolonged self-renewal. renewal. • Cells that can produce at least one type of Cells that can produce at least one type of highly differentiated descendant. highly differentiated descendant
http://www.nih.gov/news/stemcell/primer.htm NATIONAL INSTITUTES OF HEALTH May 2000 Stem Cells: A Primer Definitions Stem cells -cells that have the ability to divide for indefinite periods in culture and to give rise to specialized cells. Multipotent -giving rise to many cell types. Pluripotent-capable of giving rise to most tissues of an organIsm. Totipotent -having unlimited capability. Totipotent cells have the capacity to specialize into extraembryonic membranes and tissues, the embryo, and all postembryonic tissues and organs
http://www. http://www.nih.gov/news/stemcell stemcell/primer. /primer.htm NATIONAL INSTITUTES OF HEALTH NATIONAL INSTITUTES OF HEALTH May 2000 May 2000 Stem Cells: A Primer Stem Cells: A Primer Definitions Definitions Stem cells Stem cells - cells that have the ability to divide for indefinite cells that have the ability to divide for indefinite periods in culture and to give rise to specialized cells. periods in culture and to give rise to specialized cells. • Multipotent Multipotent -giving rise to many cell types. giving rise to many cell types. • Pluripotent Pluripotent -capable of giving rise to most tissues of an capable of giving rise to most tissues of an organism. organism. • Totipotent Totipotent - having unlimited capability. having unlimited capability. Totipotent Totipotent cells have the capacity to specialize into have the capacity to specialize into extraembryonic extraembryonic membranes and tissues, the embryo, and all postembryonic membranes and tissues, the embryo, and all postembryonic tissues and organs. tissues and organs
Pluripotent stem cells undergoLnttp://www.nih.gov/news/stemcell/primer.htm further specialization into stem cells that are committed to give rise to cells that have a particular function. These more specialized tem cells are called multipotent Totipotent Cells Multipotent stem cells are also found in adults. For example, the blood stem cell perform the critical role of continuall Pluripotent Stem Cell replenishing our supply of blood cells Blood Stem Cells Other committed Stem Cells Specialized Red Blood White Blood Cells Cells Platelets
• Pluripotent stem cells undergo further specialization into stem cells that are committed to give rise to cells that have a particular function. These more specialized stem cells are called multipotent. • Multipotent stem cells are also found in adults. For example, the blood stem cell perform the critical role of continually replenishing our supply of blood cells . http://www.nih.gov/news/stemcell/primer.htm