Massachusetts Institute of Technology VE RII TAS Harvard Medical School Brigham and women's/Massachusetts General Hosp VA Boston Healthcare System 2.79J3.96J/BE.441/HST522J RESPONSE TO PARTICLES M. Spector, Ph. D
Massachusetts Institute of Technology Massachusetts Institute of Technology Harvard Medical School Harvard Medical School Brigham and Wo Brigham and Women’s/Massachusetts General Hosp. men’s/Massachusetts General Hosp. VA Boston Healthcare System VA Boston Healthcare System 2.79J/3.96J/BE.441/HST522J 2.79J/3.96J/BE.441/HST522J RESPONSE TO PARTICLES RESPONSE TO PARTICLES M. Spector, Ph.D. M. Spector, Ph.D
BIOMATERIALS-TISSUE INTERACTIONS BIOMATERIAL TISSUE Strength Size scale 1Onm 100nm lum 10 um 100 umImm Modulus of Elasticity Fracture mechanics I sec I day 10 days 100 days Time Scale Protein Adsorption Tissue Remodeling Particles BONE Cell-cell ear Cell interactions Metal corrosion R esponse Polymer degradation Ic on ECM proteins Release Cytokines Eicosanoids E nzymes
BIOMATERIALS BIOMATERIALS -TISSUE INTERACTIONS INTERACTIONS Particles Particles BIOMATERIAL BIOMATERIAL TISSUE 10nm100nm 1µm 10 µm 100 µm 1mm 1 sec 1 day 10 days 10 days 100 days 100 days Size Scale Size Scale Time Scale Time Scale Strength Strength Modulus of Elasticity Modulus of Elasticity Fracture mechanics Fracture mechanics Protein Protein Adsorption Adsorption Cell Response Response Ion Release Release Wear Metal corrosion Metal corrosion Polymer degradation er degradation BONE Tissue Remodeling Remodeling Cell -cell interactions interactions ECM proteins ECM proteins Cytokines Cytokines Eicosanoids Eicosanoids Enzymes Enzymes
BIOMATERIALS-TISSUE INTERACTIONS Tissue Response to Implant Breakdown IMPLANT TISSUE RESPONSE Fibroblast Degradation: Fibrous tissuc Fracture (Cell Contraction?) Bone Particles Wear Macrophage Metal corrosion Polymer Degradation Osteoclast Degradation Products/Ions
BIOMATERIALS BIOMATERIALS -TISSUE INTERACTIONS: TISSUE INTERACTIONS: Tissue Response to Implant Breakdown Tissue Response to Implant Breakdown Particles Particles IMPLANT IMPLANT TISSUE RESPONSE TISSUE RESPONSE Degradation Degradation Products/Ions Products/Ions Fracture Fracture Wear Metal Corrosion Metal Corrosion Polymer Polymer Degradation Degradation Degradation: Degradation: Fibrous Tissu Fibrous Tissu e Bone Fibroblast Fibroblast Macrophage Macrophage Osteoclast Osteoclast (Cell Contraction?) (Cell Contraction?)
LOCAL AND SYSTEMIC RESPONSES SMALL PARTICLE DISEASE ° Local component Osteolysis- particle induced focal destruction of bone around the prosthesis Systemic Component Lymphadenopathy
LOCAL AND SYSTEMIC RESPONSES LOCAL AND SYSTEMIC RESPONSES SMALL PARTICLE DISEASE SMALL PARTICLE DISEASE • Local Component Local Component Osteolysis Osteolysis - particle induced particle induced focal destruction of bone focal destruction of bone around the prosthesis around the prosthesis • Systemic Component Systemic Component Lymphadenopathy Lymphadenopathy
PROGRESSION OF OSTEOLYSIS CHYLAMER CUP Image removed due to copyright considerations
PROGRESSION OF OSTEOLYSIS: “HYLAMER” CUP Image removed due to copyright considerations Image removed due to copyright considerations