Massachusetts Institute of Technology Harvard Medical School Brigham and women's Hospital VA Boston Healthcare System 279J3.96J/BE441/HST522J UNIT CELL PROCESSES ASSOCIATED WITH WOUND HEALING LV. Yannas, Ph. D and M. Spector, Ph. D
Massachusetts Institute of Technology Massachusetts Institute of Technology Harvard Medical School Harvard Medical School Brigham and Wo Brigham and Women’s Hospital men’s Hospital VA Boston Healthcare System VA Boston Healthcare System 2.79J/3.96J/BE.441/HST522J 2.79J/3.96J/BE.441/HST522J UNIT CELL PROCESSES ASSOCIATED UNIT CELL PROCESSES ASSOCIATED WITH WOUND HEALING WITH WOUND HEALING I.V. Yannas, Ph.D. and M. Spector, Ph.D. I.V. Yannas, Ph.D. and M. Spector, Ph.D
WOUND HEALING Roots of the Tissue response Resolution Slight Injur 4 Tissue Categories Connective Tissue Nonvascularized Inflammation Epitheli tissue (Vascularized tissue Nerve No Healing Muscle Healing Process Regeneration Repair(scar) cT bone CT cartilas ge Ep: epidermis Nerve Muscle: smooth Muscle: cardiac skel spontaneous
WOUND HEALING WOUND HEALING Roots of the Tissue Response Roots of the Tissue Response Injury Inflammation Inflammation (Vascularized tissue) (Vascularized tissue) Healing Healing Process Process Regeneration* Regeneration* Repair (Scar) Repair (Scar) CT: bone CT: bone CT: cartilage CT: cartilage Ep: epidermis : epidermis Nerve Muscle: smooth Muscle: smooth Muscle: cardiac, Muscle: cardiac, skel . 4 Tissu 4 Tissu e Categories Categories Connective Tissue nnective Tissue Epithelium Epithelium Nerve Muscle *spontaneous *spontaneous Resolution Resolution Slight No Healing No Healing Nonvascularized Nonvascularized tissue
RESPONSE TO IMPLANTS WOUND HEALING flury Vascular Response Inflammation Tissue of labile Tissue of and stable cells Permanent cells Framework framework Scar Intact Destroyed Regeneration Scar
RESPONSE TO IMPLANTS: RESPONSE TO IMPLANTS: WOUND HEALING WOUND HEALING Injury Vascular Response Vascular Response Inflammation Inflammation Tissue of Labile Tissue of Labile Tissue of Tissue of and Stable Cells and Stable Cells Permanent Cells Permanent Cells Framework Framework Framework Framework Scar Intact Destroyed Intact Destroyed Regeneration Scar Regeneration Scar
RESPONSE TO IMPLANTS WOUND HEALING Surgical Implantation Inc, time Vascular response Acute Clotting Inflammation Phagocytosis Granulation Neovascularization New Collagen Synthesis Tissue Tissue of labile and stable cells Tissue of permanent cells Implant movement FrameworkFramework scarring Intact Destroved (fibrous encapsulation; synovium) R egen scarring Chronic Inflammation (incorp. (fibrous encapsulation of implant) synovium hronic inflammation
RESPONSE TO IMPLANTS: RESPONSE TO IMPLANTS: WOUND HEALING WOUND HEALING Surgical Implantation Surgical Implantation Vascular Response Vascular Response Clotting Clotting Phagocytosis Phagocytosis Neovascularization Neovascularization New Collagen Synthesis New Collagen Synthesis Tissue of Labile and Stable Cells Tissue of Labile and Stable Cells Tissue of Permanent Cells Tissue of Permanent Cells Framework Framework Framework Framework Scarring Scarring Intact Destroyed Intact Destroyed (fibrous encapsulation; (fibrous encapsulation; synovium) synovium) Regen. Scarring Scarring Chronic Inflammation Chronic Inflammation (incorp. (fibrous encapsulation; (fibrous encapsulation; of implant) of implant) synovium) synovium) Chronic Inflammation Chronic Inflammation Acute Inflammation Inflammation Granulation Granulation Tissue Imp lant Movement ant Movement Inc. time Inc. time
UNIT CELL PROCESSES Regulator UCP Cell Matrix Product t Regulator Connective ECM Mitosis Tissue! Adhesion ynthesis Epithelia Protein Migration Muscle Collagen Contraction Nerve Biomaterial Endocytosis Integrin Exocytosis
UNIT CELL PROCESSES UNIT CELL PROCESSES Cell + Matrix Product + Regulator Cell + Matrix Product + Regulator Regulator Regulator Mitosis Mitosis Synthesis Synthesis Migration Migration Contraction Contraction Endocytosis Endocytosis Exocytosis Exocytosis UCP Connective Connective Tissue Epithelia Epithelia Muscle Nerve ECM Adhesion Adhesion Protein Protein Collagen Collagen Biomaterial Biomaterial Integrin Integrin