How are pluripotent stem cells derived? Pluripotent stem cells can be isolated directly from the inner cell mass of human embryos at the blastocyst stage and cultured to produce a pluripotent stem cell line. Pluripotent stem cells can be isolated from fetal tissue obtained from terminated pregnancies. Cells can be taken from the region of the fetus that is destined to develop into the testes or the ovaries http://www.nih.gov/news/stemcell/primer.htm
How are pluripotent stem cells derived? How are pluripotent stem cells derived? • Pluripotent stem cells can be isolated directly Pluripotent stem cells can be isolated directly from the inner cell mass of human embryos at from the inner cell mass of human embryos at the blastocyst blastocyst stage and cultured to produce a stage and cultured to produce a pluripotent stem cell line. pluripotent stem cell line. • Pluripotent stem cells can be isolated from fetal Pluripotent stem cells can be isolated from fetal tissue obtained from terminated pregnancies. tissue obtained from terminated pregnancies. Cells can be taken from the region of the fetus Cells can be taken from the region of the fetus that is destined to develop into the testes or the that is destined to develop into the testes or the ovaries. ovaries. http://www.nih.gov/news/stemcell/primer.htm
http://www.nih.gov/news/stemcellprimer.htm Potential Applications of pluripotent Stem cells Help to understand the events that occur during development. identification of the factors involved in the cell specialization; decision-making"genes Change the way drugs are developed and tested for safety. new medications could be initially tested using human cell lines Generation of cells and tissue that could be used for so-called cell therapies. donated organs and tissues are often used to replace ailing or destroyed tissue. the number of people suffering from these disorders far outstrips the number of organs available for transplantation
http://www.nih.gov/news/stemcell/primer.htm Potential Applications of Pluripotent Potential Applications of Pluripotent Stem Cells Stem Cells • Help to understand the events Help to understand the events that occur during development. that occur during development. – identification of the factors involved in the cell identification of the factors involved in the cell specialization; "decision specialization; "decision -making" genes . making" genes . • Change the way drugs are developed and tested for safety. Change the way drugs are developed and tested for safety. – new medications could be initially tested using human cell new medications could be initially tested using human cell lines. • Generation of cells and tissue that could be used for so Generation of cells and tissue that could be used for so -called "cell therapies." "cell therapies." – donated organs and tissues are often us donated organs and tissues are often used to replace ailing ed to replace ailing or destroyed tissue. or destroyed tissue. – the number of people suffering from these disorders far the number of people suffering from these disorders far outstrips the number of organs available for outstrips the number of organs available for transplantation. transplantation
http://www.nih.gov/news/stemcellprimer.htm Adult stem cells Multipotent stem cells can be found in some types of adult tissue. In fact, stem cells are needed to replenish the supply cells in our body that normally wear out(e.g, the blood stem cell). Multipotent stem cells have not been found for all types of adult tissue, but discoveries in this area of research are Increasing. neuronal stem cells have been isolated from the rat and mouse nervous systems. The experience in humans is more limited a kind of cell that may be a neuronal stem cell has been isolated from adult brain tissue
http://www.nih.gov/news/stemcell/primer.htm Adult Stem Cells Adult Stem Cells • Multipotent stem cells can be found in some types of Multipotent stem cells can be found in some types of adult tissue. In fact, stem cells are needed to replenish adult tissue. In fact, stem cells are needed to replenish the supply cells in our body that normally wear out ( the supply cells in our body that normally wear out (e.g., the blood stem cell). the blood stem cell). • Multipotent stem cells have not been found for all types Multipotent stem cells have not been found for all types of adult tissue, but discoveries in this area of research are of adult tissue, but discoveries in this area of research are increasing. increasing. – neuronal stem cells have been isolated from the rat neuronal stem cells have been isolated from the rat and mouse nervous systems. The experience in and mouse nervous systems. The experience in humans is more limited. humans is more limited. – a kind of cell that may be a neuronal stem cell has a kind of cell that may be a neuronal stem cell has been isolated from adult brain tissue. been isolated from adult brain tissue