2. 79J/3.96J/BEH 441J/HST522J Biomaterials-Tissue Interactions CONTENTS Introduction Chapter 1. Irreversible Healing of Extracellular Matrix Chapter 2. Cell-Matrix Interactions Chapter 3. Synthesis of Tissues and Organs TEXT: I.V. Yannas. Tissue and Organ regeneration in Adults. New York: Springer, 2001
2.79J/3.96J/BEH.441J/HST522J Biomaterials-Tissue Interactions CONTENTS Introduction. Chapter 1. Irreversible Healing of Extracellular Matrix. Chapter 2. Cell-Matrix Interactions. Chapter 3. Synthesis of Tissues and Organs. TEXT: I. V. Yannas. Tissue and Organ Regeneration in Adults. New York: Springer, 2001. 1
Introduction How are biomaterials used? Brief survey from organs to cells
Introduction. How are biomaterials used? Brief survey: from organs to cells. 2
How are biomaterials used? Today's brief survey: from organ to cell outline of survey 1. Five Therapies for the Missing Organ Examples of permanent implants Examples of regenerated organs 2. Tissue and organ regeneration viewed asas processes of chemical synthesis 3. What is the mechanism of organ regeneration? 4. Cell-matrix interactions 5. The unit cell process
How are biomaterials used? Today’s brief survey: from organ to cell outline of survey 1. Five Therapies for the Missing Organ Examples of permanent implants Examples of regenerated organs 2. Tissue and organ regeneration viewed as as processes of chemical synthesis. 3. What is the mechanism of organ regeneration? 4. Cell-matrix interactions. 5. The unit cell process. 3
Five Therapies for the Missing organ 1. Transplantation( e.g., kidney transplant, heart transplant, liver transplant) 2. Autografting(e. g, heart bypass, skin grafting) 3. Permanent implants(e. g, hip prosthesis, pacemaker, breast implant) 4. In vitro synthesis(e.g, epidermis) 5. In vivo synthesis or regeneration(e.g, skin, nerves, conjunctiva). Remarks: Biomaterials are used in therapies #3, 4 and 5. tissue engineering includes therapies #4 and 5
Five Therapies for the Missing Organ 1. Transplantation (e.g., kidney transplant, heart transplant, liver transplant) 2. Autografting (e.g., heart bypass, skin grafting). 3. Permanent implants (e.g., hip prosthesis, pacemaker, breast implant) 4. In vitro synthesis (e.g., epidermis) 5. In vivo synthesis or regeneration (e.g., skin, nerves, conjunctiva). Remarks: Biomaterials are used in therapies #3, 4 and 5. Tissue engineering includes therapies #4 and 5. 4
Therapy #3: Example of permanent implant Pelvis Socket or cup Cement Stem Detail Femur Another example of permanent implant Abiocor M Implantable Replacement Heart (http://www.abiocor.com
Therapy # 3 : Example of permanent implant Another example of permanent implant AbioCor™ Implantable Replacement Heart (http://www.abiocor.com) 5