2.79J/3.96JBEH441JHST522J Biomaterials-Tissue Interactions Outline of three lectures on ECMs A Irreversible healing of ECMs in different organs B Structure and function of naturally occurring ECMs C Synthesis of biologically active ECM models
2.79J/3.96J/BEH.441J/HST522J Biomaterials-Tissue Interactions Outline of three lectures on ECM s A. Irreversible healing of ECMs in different organs. B. Structure and function of naturally occurring ECMs. C. Synthesis of biologically active ECM models. 1
B Structure and function of naturally occurring ECMs
B. Structure and function of naturally occurring ECMs 2
a biologically active model of ECM acts as an insoluble regulator of cell function image removed due to copyright considerations
A biologically active model of ECM acts as an insoluble regulator of cell function image removed due to copyri image removed due to copyright consi ght considderati erations ons 3
Definition of unit cell process Soluble Regulator A Insoluble Product Soluble Cell Regulate Regulator B Control volume dv Unit cell process confined conceptually in a control volume d
Definition of unit cell process 4 Cell + Insoluble Regulator Product Soluble Regulator A Soluble Regulator B Control volume dV Unit cell process confined conceptually in a control volume dV
The Extracellular Matrices(ECMS Part I (summary of structure and function) Insoluble macromolecular networks Structure varies with organ; but different ECMs comprise few types of macromolecules(mostly collagen, elastin, proteoglycans )plus water(65%) ECM does not migrate, proliferate, synthesize proteins or contain DNA! Give and take of signals with cells. Ligands on ECM surface interact specifically with cell receptors (integrins) Partly determine the state of differentiation of cells
The Extracellular Matrices (ECMs) Part I. (summary of structure and function) 5 Insoluble macromolecular networks. Structure varies with organ; but different ECMs comprise few types of macromolecules (mostly collagen, elastin, proteoglycans) plus water (65%). ECM does not migrate, proliferate, synthesize proteins or contain DNA! Give and take of signals with cells. Ligands on ECM surface interact specifically with cell receptors (integrins). Partly determine the state of differentiation of cells