C CellMatrix Interactions A How cells pull onto and deform the matrix to which they attach themselves B Cell-matrix interactions control the spontaneous closure of wounds in organs. C. What happens when regeneration is induced?
C. Cell-Matrix Interactions A. How cells pull onto and deform the matrix to which they attach themselves. B. Cell-matrix interactions control the spontaneous closure of wounds in organs. C. What happens when regeneration is induced?
C. What happens when regeneration is induced? Closure of a defect by contraction(and scar synthesis)appears to block regeneration in the adult Certain ECM analogs that selectively lock contraction have been shown to induce partial regeneration in adults skin, peripheral nerves, conjunctiva) Under the same conditions, neither addition of growth factors nor of cell suspensions have blocked contraction nor have they induced regeneration
C. What happens when regeneration is induced? • Closure of a defect by contraction (and scar synthesis) appears to block regeneration in the adult. • Certain ECM analogs that selectively lock contraction have been shown to induce partial regeneration in adults (skin, peripheral nerves, conjunctiva). • Under the same conditions, neither addition of growth factors nor of cell suspensions have blocked contraction nor have they induced regeneration
Hypothesis: Regeneration requires selective blocking of contraction
Hypothesis: Regeneration requires selective blocking of contraction
a brief review of the obvious effects of closure by contraction
A brief review of the obvious effects of closure by contraction
Isolated cell(fibroblast) contracts surface of thin silicone film, floating on oil. Buckling results Image removed due to copyright considerations See Figure 9. 1 in Yannas, L.V. Tissue and Organ Regeneration in Adults New York: Springer-Verlag, 2001
Isolated cell (fibroblast) contracts surface of thin silicone film, floating on oil. Buckling results. Image removed due to copyright considerations. See Figure 9.1 in Yannas, I. V. Tissue and Organ Regeneration in Adults. New York: Springer-Verlag, 2001. Image removed due to copyright considerations. See Figure 9.1 in Yannas, I. V. Tissue and Organ Regeneration in Adults. New York: Springer-Verlag, 2001