Glucocorticoid drugs (3) Septic shock中毒性休克: e larger dose, short-term, combined with antimicrobial drugs o(4)Hemological diseases: acute lymphocytic leukemia, lymphomas, aplastic anemia, hemolytic anemia, leukocytopenia, thrombocytopenia, etc. o( 5) Replacement therapy o(6) Topical applications: skin, eye, respiratory tract, joint (local injection)
(3) Septic shock 中毒性休克: larger dose, short-term, combined with antimicrobial drugs (4) Hemological diseases: acute lymphocytic leukemia, lymphomas, aplastic anemia, hemolytic anemia, leukocytopenia, thrombocytopenia, etc. (5) Replacement therapy (6) Topical applications: skin, eye, respiratory tract, joint (local injection) Glucocorticoid drugs
Glucocorticoid drugs 0 4. Adverse effects D(1) Effects resulting from continued used of large doses a) Hypercorticism-like syndrome(医源性肾上腺皮质功能 n iE): central obesity(moon face buffalo hump, etc. hypertension; glycosuria, hypokalemia; muscular atrophy, etc o b) Increasing susceptibility to infections: o specific antimicrobial drugs should be administered with GCs 3 FT n c)Digestive system: peptic ulcers, etc I FT
4. Adverse effects (1) Effects resulting from continued used of large doses a) Hypercorticism-like syndrome (医源性肾上腺皮质功能 亢进): central obesity (moon face, buffalo hump, etc.); hypertension; glycosuria, hypokalemia; muscular atrophy, etc. b) Increasing susceptibility to infections: specific antimicrobial drugs should be administered with GCs c) Digestive system: peptic ulcers, etc. Glucocorticoid drugs
Glucocorticoid drugs o d cardiovascular system: hypertension, arteriosclerosis e) Myopathy肌肉萎缩 and osteoporosis骨质疏松: vertebral compression fractures, spontaneous fractures, especially in postmenopausal women o f CNS: behavioral disturbances, induction of epileptic seizures u g Inhibition or arrest of growth in children h)skin(伤口延缓愈合)
d) Cardiovascular system: hypertension, arteriosclerosis e) Myopathy 肌肉萎缩 and osteoporosis 骨质疏松: vertebral compression fractures, spontaneous fractures, especially in postmenopausal women f) CNS: behavioral disturbances, induction of epileptic seizures g) Inhibition or arrest of growth in children h) skin（伤口延缓愈合） Glucocorticoid drugs
欣快 (有时出现抑制或精神 症状及情绪不稳定) 水牛背 满月脸 Adverse effects of 高血压 glucocorticoid drugs (有时有) Effects resulting from continued used of large doses 皮肤变薄入\w、+腹部肥胖 心 股骨颈坏死 上下胶消瘦/一易于感染 创伤不易愈合 还有:负氨平衡、骨质疏松、食欲增加、 低血钾、高血蒂倾向、消化性溃疡
Adverse effects of glucocorticoid drugs Effects resulting from continued used of large doses
Glucocorticoid drugs 0(2 Withdrawal syndrome a) iatrogenic adrenocortical insufficiency(医源性的肾上 腺皮质功能不全): suppression of hypothalamic pituitary-adrenal axis o b) Exacerbation of the underlying diseases(rebound) n (3) Contraindications o psychiatric disorders; epilepsy; active peptic ulcers; fractures; hypercorticism; severe hypertension diabetes mellitus; viral or fungal infections, etc
(2) Withdrawal syndrome a) iatrogenic adrenocortical insufficiency (医源性的肾上 腺皮质功能不全): suppression of hypothalamicpituitary-adrenal axis b) Exacerbation of the underlying diseases (rebound) (3) Contraindications psychiatric disorders; epilepsy; active peptic ulcers; fractures; hypercorticism; severe hypertension; diabetes mellitus; viral or fungal infections, etc. Glucocorticoid drugs