Glucocorticoid drugs o(4) Effects on immune and allergy n Suppressing immunological functions 01)抑制巨噬细胞对抗原的吞噬和处理 2)使敏感动物的淋巴细胞破坏解体(大鼠、小鼠、家兔) 3)干扰淋巴组织在抗原作用下的分裂和增殖,阻断致敏T细 胞诱发的单核巨噬细胞的募集
(4) Effects on immune and allergy Suppressing immunological functions 1) 抑制巨噬细胞对抗原的吞噬和处理 2) 使敏感动物的淋巴细胞破坏解体 (大鼠、小鼠、家兔) 3) 干扰淋巴组织在抗原作用下的分裂和增殖，阻断致敏T细 胞诱发的单核巨噬细胞的募集 Glucocorticoid drugs
Glucocorticoid drugs o(4) Effects on immune and allergy n Suppressing immunological functions o a)inhibit DNA, RNA and protein synthesis, and induce the dna degeneration of lymphocytes o b inducing apoptosis of lymphocytes o c)inhibiting transcription factor nuclear factor KB (NF- KB)activity and increase expression of I KB a
(4) Effects on immune and allergy Suppressing immunological functions a) inhibit DNA, RNA and protein synthesis, and induce the DNA degeneration of lymphocytes b) inducing apoptosis of lymphocytes c) inhibiting transcription factor nuclear factor B (NF- B) activity and increase expression of I B Glucocorticoid drugs
Glucocorticoid drugs o(4) Effects on immune and allergy 3c4 n Suppressing allergic reaction D inhibit the allergic mediator (histamine, 5-HT, bradykinin) production from mast cells at Cal
(4) Effects on immune and allergy Suppressing allergic reaction inhibit the allergic mediator (histamine, 5-HT, bradykinin) production from mast cells Glucocorticoid drugs
Glucocorticoid drugs 0(5 Anti-shock Septic shock o a) improving cardiovascular functions, decrease the sensitivity to vasoconstrictor substance o b inhibiting the production of inflammatory factors o c)stabilizing lysosome membrane: decreasing the release of myocardial depressant factor(MDF) n d increasing the tolerance to endotoxin from bacteria
(5) Anti-shock Septic shock a) improving cardiovascular functions, decrease the sensitivity to vasoconstrictor substance b) inhibiting the production of inflammatory factors c) stabilizing lysosome membrane: decreasing the release of myocardial depressant factor (MDF) d) increasing the tolerance to endotoxin from bacteria Glucocorticoid drugs
Glucocorticoid drugs n(6)Other effects o a) antipyretic effects o b) effects on blood and blood-forming organs o red blood cells; lym phocytes l neutrophils (function l) platelets↑ n c)skeletal system: osteoporosis o d cNS: increasing excitability(elevated mood, euphoria k, insomnia BHE, restlessness, increased motor activity)
(6) Other effects a) antipyretic effects b) effects on blood and blood-forming organs red blood cells ; lymphocytes ; neutrophils (function ); platelets c) skeletal system: osteoporosis d) CNS: increasing excitability (elevated mood, euphoria 欣快, insomnia 失眠,restlessness, increased motor activity) Glucocorticoid drugs